69
Participants
Start Date
February 28, 2002
Primary Completion Date
May 31, 2008
Study Completion Date
May 31, 2008
Zolpidem
The benzodiazepine receptor agonist (BzRA), zolpidem was given in an initial dose of 5 mg by mouth every night, 30 minutes prior to bedtime. The dose was increased to a maximum of 10 mg after the first week if there was no improvement in overall symptoms (CGI score of 4 or \>). The dose was decreased to 5 mg if side effects occurred.
Escitalopram
The antidepressant, escitalopram was initiated at 5 mg by mouth every night, 30 minutes prior to bedtime. If there were no side effects, the dose was increased every four days until the target dose of 20 mg (maximum dose) was reached by day 13. If significant side effects appeared, the highest tolerated dose was used.
Placebo
A placebo capsule was given with instructions to take it every night by mouth, 30 minutes prior to bedtime.
Western Psychiatric Institute and Clinic/ University of Pittsburgh Medical Center, Pittsburgh
National Institute of Mental Health (NIMH)
NIH
University of Pittsburgh
OTHER