Stem Cell Transplant for Bone Marrow Failure Syndromes

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

June 30, 2000

Primary Completion Date

March 31, 2009

Study Completion Date

March 31, 2009

Conditions
Diamond-Blackfan AnemiaKostmann's NeutropeniaShwachman-Diamond Syndrome
Interventions
PROCEDURE

Stem cell transplant

Stem cell transplant on Day 0 - healthy marrow from an unrelated individual. A minimum of 1.0 x 10\^9/kg nucleated cells/kg ideal body weight will be collected with a goal of 2.0 x 10\^9/kg.

DRUG

Fludarabine monophosphate

fludarabine 175 mg/m\^2 (total) on Days -6 through -3.

PROCEDURE

Total lymphoid irradiation

Dose 500 cGy radiation therapy to specific areas of the body

DRUG

Busulfan

Busulfan 8 mg/kg (total) on Days - 8 and -7 (orally or through the catheter),

BIOLOGICAL

anti-thymocyte globulin

anti-thymocyte globulin (ATG) 15 mg/kg on days -2 and -1 via catheter

Trial Locations (1)

55455

University of Minnesota Medical Center, Minneapolis

All Listed Sponsors
lead

Masonic Cancer Center, University of Minnesota

OTHER

NCT00176878 - Stem Cell Transplant for Bone Marrow Failure Syndromes | Biotech Hunter | Biotech Hunter