19
Participants
Start Date
August 31, 2002
Primary Completion Date
August 31, 2012
Study Completion Date
August 31, 2014
Stem Cell Transplant
IV on Day 0
Fludarabine
30mg/m\^2 IV Day -7 through Day -3
Melphalan
140 mg/m\^2 IV Day -1
Anti-thymocyte globulin (ATG)
30 mg/kg IV Day -5 through Day -1
Campath 1H
0.2 mg/kg IV X 5 days (used as an alternative to Anti-thymocyte globulin (ATG) if unable to tolerate ATG) Day -10 through Day -6
Cyclosporin A
2.5 mg/kg IV every 12 hours (adults) or every 8 hours (children \<40 kg) maintaining a level of \>200mg/L Day -3 until Day +180 when, if no GVHD, the dose will be tapered 10% per week beginning on day 181
Mycophenolate mofetil
15 mg/kg IV or orally bid and discontinued on Day +45 unless GVHD is present
Intravenous immunoglobulin (IVIG)
500 mg/kg IV weekly beginning on Day +7 until Day +100
Masonic Cancer Center University of Minnesota, Minneapolis
Masonic Cancer Center, University of Minnesota
OTHER