Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer

Topotecan will be provided as capsules for oral administration and will be administered at least 3 hours before radiation therapy.

For radiation therapy, subjects will receive 180 centigray (cGy) per fraction to a total dose of 4500 cGy to the pelvis using a 3 or 4 field technique and high energy photons (\>=6 megavolt \[mv\]).