Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC

PHASE3CompletedINTERVENTIONAL
Enrollment

840

Participants

Timeline

Start Date

March 31, 2000

Primary Completion Date

March 31, 2011

Study Completion Date

March 31, 2011

Conditions
Oral CancerOropharynx CancerHypopharynx CancerLarynx Cancer
Interventions
PROCEDURE

Conventional radiotherapy 70 Gy in 7 weeks

2 gy per fraction, 1 fraction per day, 5 fractions per week

PROCEDURE

middle accelerated radiotherapy 70 Gy in 6 weeks

5 x 2gy/week until 40 Gy in 20 fractions and 4 weeks, then 2 fractions of 1.5Gy per day for 30 additional Gy in 2 weeks

PROCEDURE

very accelerated radiotherapy 64.8 Gy in 3.5 weeks

2 fractions of 1.8 Gy per day for 64.8 Gy in 3.5 weeks

DRUG

5FU, Paraplatin

5FU 600mg/m²/D, Paraplatin 70mg/m²/D In arm 1: D1-4, 3 cycles during Rth (D1, D22, D43) In arm 2: D1-5, 2 cycles during Rth (D1, D29)

Trial Locations (2)

94800

Institut Gustave Roussy, Villejuif

37 044

CHU de Tours, Tours

All Listed Sponsors
lead

Groupe Oncologie Radiotherapie Tete et Cou

OTHER

NCT00158652 - Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC | Biotech Hunter | Biotech Hunter