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Participants
Start Date
September 30, 2005
Primary Completion Date
May 31, 2012
Study Completion Date
July 31, 2012
Conjugated equine estrogens 0.45 mg/day
Pill, 1 pill taken daily each month for the study duration
Transdermal estradiol, 50 mcg/day
Patch; 1 patch is applied to the skin weekly. Patch site is rotated on a weekly basis.
Micronized progesterone, 200 mg/day x 12 d/month
capsule, 1 capsule taken daily for the first 12 days of each month for the study duration
CEE , progesterone, estradiol patch or placebo for each
CEE 0.45mg 1 PO QD Progesterone 200 mg 1 PO HS first 12 days of the month estradiol patch use 1 per week
CEE, progesterone, transdermal patch or the placebo
CEE 0.45 mg 1 PO QD or placebo equivalent Prometrium 200 mg 1 PO qHS for first 12 dasy of each month or placebo equivalent transdermal patch 0.05 mg use 1 patch per week or placebo equivalent
Columbia Presbyterian Hospital, New York
Albert Einstein College of Medicine, The Bronx
Mayo Clinic, Rochester
University of Utah, Salt Lake City
University of California, San Francisco, San Francisco
University of Washington/VA Puget Sound, HCS, Seattle/Tacoma
Kronos Longevity Research Institute, Phoenix
Yale University Medical Center, New Haven
Brigham and Women's Hospital, Boston
Lead Sponsor
Collaborators (1)
Albert Einstein College of Medicine
OTHER
Brigham and Women's Hospital
OTHER
Columbia University
OTHER
Mayo Clinic
OTHER
University of California, San Francisco
OTHER
University of Utah
OTHER
University of Washington
OTHER
Yale University
OTHER
Kronos Longevity Research Institute
OTHER