75
Participants
Start Date
March 31, 2004
Study Completion Date
November 30, 2007
IV amikacin
5-7.5 mg/kg every 8 hrs or previous dose; start at previous recent stable dose then monitor serum levels and adjust dose, if needed, per standard clinical practice at the site
PO azithromycin
250 mg once daily
IV ceftazidime
50 mg/kg every 8 hours, up to 2 grams every 8 hours
PO ciprofloxacin
500 mg every 12 hours if weight \<50 kg 750 mg every 12 hours if weight ≥50 kg
IV meropenem
40 mg/kg every 8 hours, up to 2 grams every 8 hours
IV piperacillin-tazobactam
100 mg/kg of piperacillin component every 6 hours, up to 3 grams every 6 hours; antibiotic combination formulated in a fixed ratio, thus dosing is described for first component only
IV ticarcillin-clavulanate
100 mg/kg of ticarcillin component every 6 hours, up to 3 grams every 6 hours; antibiotic combination formulated in a fixed ratio, thus dosing is described for first component only
IV tobramycin
2.5-3.3 mg/kg every 8 hrs or previous dose; start at previous recent stable dose then monitor serum levels and adjust dose, if needed, per standard clinical practice at the site
University of Pittsburgh Medical Center, Pittsburgh
Ohio State University, Columbus
University of Iowa, Iowa City
Washington University St. Louis, St Louis
Baylor College of Medicine, Houston
University of Washington Medical Center, Seattle
University of Cincinnati, Cincinnati
Children's Hospital and Regional Medical Center, Seattle
Cystic Fibrosis Foundation
OTHER
Seattle Children's Hospital
OTHER