Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

October 31, 1999

Primary Completion Date

December 31, 2004

Study Completion Date

December 31, 2005

Conditions
Septic ShockSevere SepsisInfections
Interventions
DRUG

norepinephrine and dobutamine

continuous infusion of norepinephrine titrated to maintain a mean arterial pressure at 70mmHg or more and dobutamine could be added as a continuous infusion when cardiac index was of less than 2.5 liters per squared meter of body surface

DRUG

epinephrine plus placebo of dobutamine

epinephrine was titrated to maintain a mean arterial pressure at 70mmHg or more and placebo of dobutamine was titrated in case of a cardiac index lower than 2.5 liters per squared meters of body surface

Trial Locations (15)

13009

Réanimation Polyvalente - Hôpital Nord, Marseille

54035

Réanimation Chirurgicale - Hôpital Central, Nancy

Service de Réanimation Médicale - Hôpital Central, Nancy

59100

Réanimation - CH Victor Provo, Roubaix

75005

Service d'anesthésiologie - HIA Val de Grâce, Paris

75010

Réanimation Médicale - Hôpital Saint Louis, Paris

75014

Réanimation Polyvalente - Hôpital Saint Joseph, Paris

75908

Réanimation Médicale - Hôpital Georges Pompidou, Paris

78157

Réanimation Médicale - Hôpital André Mignot, Le Chesnay

78303

Réanimation Médicale - CHI de Poissy, Poissy

87000

Réanimation Polyvalente - Hôpital Dupuytren, Limoges

91100

Réanimation Polyvalente - Hôpital de Corbeil, Corbeil

92380

Service de Réanimation Médicale - Hôpital Poincaré, Garches

92700

Réanimation Médicale - Hôpital Louis Mourier, Colombes

94800

Réanimation Polyvalente - Institut Gustave Roussy, Villejuif

All Listed Sponsors
collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

lead

University of Versailles

OTHER