NCT00147537 - Combination Study Of CP-751,871 With Paclitaxel And Carboplatin In Advanced Lung Cancer | Biotech Hunter

Enrollment

282

Participants

Timeline

Start Date

February 28, 2005

Primary Completion Date

August 31, 2011

Study Completion Date

August 31, 2011

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

CP-751,871

"Phase 2 Arm A:~CP-751,871 20 mg/kg IV over 2.5 hours up to 17 cycles"

DRUG

paclitaxel

"Phase 2 Arm A:~Paclitaxel 200 mg/m2, IV over 3 hours up to 6 cycles~Phase 2 Arm B:~Paclitaxel 200 mg/m2, IV over 3 hours up to 6 cycles"

DRUG

carboplatin

"Phase 2 Arm A:~Carboplatin AUC 6, IV over 15-60 minutes up to 6 cycles~Phase 2 Arm B:~Carboplatin AUC 6, IV over 15-60 minutes up to 6 cycles"

DRUG

CP-751,871

Phase 1b Dose Escalation/Expansion: CP-751,871 20 mg/kg IV over 2.5 hours (up to 17 cycles) Phase 1b Erlotinib Extension: CP-751,871 20 mg/kg IV over 2.5 hours (up to 17 cycles)

DRUG

paclitaxel

Phase 1b Dose Escalation/Expansion: paclitaxel 200 mg/m2, IV over 3 hours (up to 6 cycles) Phase 1b Erlotinib Extension: paclitaxel 200 mg/m2, IV over 3 hours (up to 6 cycles)

DRUG

carboplatin

Phase 1b Dose Escalation/Expansion: carboplatin AUC 6, IV over 15-60 minutes (up to 6 cycles) Phase 1b Erlotinib Extension: carboplatin AUC 6, IV over 15-60 minutes (up to 6 cycles)

DRUG

erlotinib

Phase 1b Erlotinib Extension: erlotinib 150 mg/day orally every day (up to 17 cycles)

Trial Locations (31)

10043

Pfizer Investigational Site, Orbassano (TO)

10461

Pfizer Investigational Site, The Bronx

10467

Pfizer Investigational Site, The Bronx

19111

Pfizer Investigational Site, Philadelphia

21204

Pfizer Investigational Site, Baltimore

28041

Pfizer Investigational Site, Madrid

32216

Pfizer Investigational Site, Jacksonville

32224

Pfizer Investigational Site, Jacksonville

38104

Pfizer Investigational Site, Memphis

38120

Pfizer Investigational Site, Memphis

38671

Pfizer Investigational Site, Southaven

38834

Pfizer Investigational Site, Corinth

40065

Pfizer Investigational Site, Shelbyville

40202

Pfizer Investigational Site, Louisville

40207

Pfizer Investigational Site, Louisville

40217

Pfizer Investigational Site, Louisville

40241

Pfizer Investigational Site, Louisville

41013

Pfizer Investigational Site, Seville

47130

Pfizer Investigational Site, Jeffersonville

55905

Pfizer Investigational Site, Rochester

63110

Pfizer Investigational Site, St Louis

63141

Pfizer Investigational Site, Creve Coeur

63376

Pfizer Investigational Site, City of Saint Peters

77030

Pfizer Investigational Site, Houston

85719

Pfizer Investigational Site, Tucson

85724

Pfizer Investigational Site, Tucson

90048

Pfizer Investigational Site, Los Angeles

94904

Pfizer Investigational Site, Greenbrae

85724-5024

Pfizer Investigational Site, Tucson

H3T 1E2

Pfizer Investigational Site, Montreal

08907

Pfizer Investigational Site, L'Hospitalet de Llobregat