Capecitabine, Oxaliplatin, Bevacizumab and Radiation Therapy in Patients With Biliary Tract and Gallbladder Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

December 31, 2004

Primary Completion Date

July 31, 2007

Study Completion Date

April 30, 2011

Conditions
Biliary Tract CancerGallbladder Adenocarcinoma
Interventions
DRUG

Capecitabine

Given orally for 14 consecutive days (days 1-14) followed by a week of no capecitabine then another week of 14 consecutive days (days 21-28).

DRUG

Oxaliplatin

Given intravenously once weekly during weeks 1, 2, 4 and 5 on days 1, 8, 22 and 29

DRUG

Bevacizumab

Given intravenously every two weeks during weeks 1, 3 and 5 on days 1, 15 and 29.

PROCEDURE

Radiation therapy

Once daily for 5 days (Monday through Friday) for a total of 28 treatments.

Trial Locations (3)

02114

Massachusetts General Hospital, Boston

02115

Dana-Farber Cancer Institute, Boston

02118

Beth Israel Deaconess Medical Center, Boston

Sponsors
All Listed Sponsors
collaborator

Dana-Farber Cancer Institute

OTHER

collaborator

Beth Israel Deaconess Medical Center

OTHER

collaborator

Brigham and Women's Hospital

OTHER

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Sanofi-Synthelabo

INDUSTRY

collaborator

Hoffmann-La Roche

INDUSTRY

lead

Massachusetts General Hospital

OTHER