Phase I/II Dose-escalation Study of Lutetium-177-labeled cG250 in Patients With Advanced Renal Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

February 28, 2005

Primary Completion Date

January 31, 2011

Study Completion Date

January 31, 2011

Conditions
Metastatic Renal Cell Carcinoma
Interventions
DRUG

111-In-DOTA-cG250

On Day 1, each subject received a single intravenous (IV) infusion of 10 mg of cG250 coupled to DOTA and labeled with 5 mCi of 111-In.

DRUG

177-Lu-DOTA-cG250

On Day 8, 9, or 10, each subject received a single IV infusion of 10 mg of cG250 coupled to DOTA and labeled with a dose of 177-Lu at a starting dose of 30 mCi/m\^2 in the initial cohort.

Trial Locations (1)

6500HB

University Medical Center Nijmegen, Nijmegen

All Listed Sponsors
collaborator

Radboud University Medical Center

OTHER

lead

Ludwig Institute for Cancer Research

OTHER