R-ICE Versus R-DHAP in Patients Aged 18-65 With Relapse Diffuse Large B-cell Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

481

Participants

Timeline

Start Date

June 30, 2003

Primary Completion Date

October 31, 2008

Study Completion Date

October 31, 2008

Conditions
Lymphoma, Large-Cell, Diffuse
Interventions
DRUG

Rituximab

375 mg/m² D-2/D1

DRUG

Etoposide

100 mg/m² D1-D2-D3

DRUG

Carboplatine

max 800mg D2

DRUG

Ifosfamide + Mesna

5 g/m² from D2 to D13

DRUG

Cisplatine

100 mg/m² from D1 to D13

DRUG

Cytosine Arabinoside

2000 mg/m²/12 h D2 D3

DRUG

Dexamethasone

40 mg From D1 to D4

PROCEDURE

Autologous Stem Cell Transplantation

DRUG

BCNU

300mg/m² on D-6

DRUG

Etoposide

200 mg/m² from D-6 to D-3

DRUG

Cytarabine

100 mg/m² from D-6 to D-3

DRUG

Melphalan

140 mg/m² on D-2

Trial Locations (10)

10021

Memorial Sloan Kettering Cancer Center, New York

Unknown

Australian leukemia and lymphoma group, Sydney

Groupe d'atude des lymphome de l'adulte, Yvoir

Czech Lymphoma study group, Prague

Hospital district of south west Finland, Turku

German high grade non hodgkin's lymphoma group, Hamburg

Israel Society of Hematology, Tel Litwinsky

Nordic center, Uppsala

Schweirische Arbeitsgruppe fur klinische Krebsforschung, Lausanne

National cancer research institute, London

All Listed Sponsors
lead

Lymphoma Study Association

OTHER

NCT00137995 - R-ICE Versus R-DHAP in Patients Aged 18-65 With Relapse Diffuse Large B-cell Lymphoma | Biotech Hunter | Biotech Hunter