Cisplatin, CPT-11 and Celecoxib With Radiation Therapy and Surgery for Operable Esophageal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

January 31, 2002

Primary Completion Date

August 31, 2004

Study Completion Date

September 30, 2017

Conditions
Esophageal Cancer
Interventions
DRUG

Cisplatin

Given weekly on weeks 1, 2, 4 and 5 during radiation therapy.

DRUG

Irinotecan

Given weekly on weeks 1, 2, 4 and 5 during radiation therapy

DRUG

Celecoxib

Given twice daily 3 days prior to radiation and up until one week prior to surgery. It will then be started again once the participant is released from the hospital following surgery for 26 weeks.

PROCEDURE

Radiation Therapy

5 days a week for 5-6 weeks

PROCEDURE

Esophagectomy

Within 4-8 weeks of chemoradiation therapy

Trial Locations (2)

02114

Massachusetts General Hospital, Boston

02115

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Brigham and Women's Hospital

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

Pharmacia

INDUSTRY

lead

Dana-Farber Cancer Institute

OTHER