100
Participants
Start Date
June 30, 2002
Primary Completion Date
November 30, 2008
Study Completion Date
May 31, 2011
prednisone
Induction Phase: Given orally on days 1-28
doxorubicin
Induction Phase: Given intravenously on day 1 and day 2 CNS Therapy: Given intravenously on day 1 Intensification: Given day 1 of each cycle
vincristine
"Induction: Given intravenously on days 1, 8, 15, and 22. If complete remission not achieved, will be given on days 29, 36 and 43.~CNS Therapy: Given intravenously on day 1. Intensification: Given intravenously on day 1 of each cycle. Continuation: Given intravenously on day 1 of each cycle"
methotrexate
Induction: Given intravenously on day 3. CNS Therapy: Given intrathecally 4 times over two weeks Intensification: Given intrathecally every 18 weeks Continuation: Given intravenously weekly and intrathecally every 18 weeks
asparaginase
Induction: Given into the muscle on day 5
dexamethasone
Intensification: Given orally on days 1-5 of each cycle
cranial radiation
Given in 10 daily treatments during CNS therapy phase
leucovorin
Induction: Given intravenously or orally 36 hours after methotrexate
cytarabine
Induction: Given intrathecally days 1, 15, 29 CNS Therapy: Given intrathecally 4 times over 2 weeks Intensification: Given intrathecally every 18 weeks Continuation: Given intrathecally every 18 weeks
hydrocortisone
Induction: Given intrathecally on days 15 and 29. Intensification: Given intrathecally every 18 weeks. Continuation: Given intrathecally every 18 weeks.
6-mercaptopurine (6-MP)
CNS Therapy: Taken orally on days 1-14. Intensification: Taken orally on days 1-14. Continuation: Taken orally on days 1-14.
e. coli L-asparaginase
Intensification: Given in to the muscle weekly.
Dana-Farber Cancer Institute, Boston
Massachusetts General Hospital, Boston
University Of Columbia Medical Center, New York
Manitoba Blood & Marrow Transplant Program CancerCare Manitoba, Winnipeg
McMaster University Medical Center, Hamilton
Queen's University, Kingston
London Health Sciences Centre, London
Sunnybrook Health Sciences Centre, Toronto
Hospital Maisonneuve-Rosemont, Montreal
Royal Victoria Hospital, Montreal
Saskatoon Cancer Centre, Saskatoon
Queen Elizabeth II, Halifax
Brigham and Women's Hospital
OTHER
Massachusetts General Hospital
OTHER
Queen Elizabeth II Health Sciences Centre
OTHER
Dana-Farber Cancer Institute
OTHER