Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients

NACompletedINTERVENTIONAL
Enrollment

1,223

Participants

Timeline

Start Date

April 30, 2005

Primary Completion Date

December 31, 2011

Study Completion Date

May 31, 2012

Conditions
Critical IllnessSepsisMultiple Organ Failure
Interventions
OTHER

Glutamine

0.35 gm/kg/day parenterally and 30 gms/day enterally

OTHER

Antioxidants

500 micrograms of selenium/day parenterally and selenium 300 microgram, zinc 20 mg, beta carotene 10 mg, vitamine E 500 mg and vitamin C 1500 mg per day enterally

OTHER

Glutamine + Antioxidants

0.35 g/kg/day glutamine parenterally and 30 g/day of glutamine enterally. 500 mcg selenium parenterally plus the following administered enterally: selenium 300 mcg, zing 20 mg, beta-carotene 10 mg, vitamin E 500 mg and vitamin C 1500mg

OTHER

Placebo

Normal saline intravenously and EN placebo formula (from Fresenius Kabi, Germany)

Trial Locations (34)

6431

University of Texas, Houston

24105

University Medical Center Schleswig-Holstein, Kiel

40202

University of Louisville, Louisville

45409

Miami Valley Hospital, Dayton

80045

Univ. of Colorado at Denver and Health Sciences Center, Aurora

05401

Fletcher Allan Centre, Burlington

Unknown

UZ Brussels, Brussels

Universitatsklinikum der Ernst-Moritz-Arndt-Universitat, Greifswald

Asklepios Kliniken Hamburg Altona, Hamburg

Universitatsklinikum Schleswig-Holstein Campus Luebeck, Lübeck

University of Zurich, Zurich

B-4000

University Hospital, Liège

T5H 3V9

Royal Alexandra Hospital, Edmonton

T6L 5X8

Grey Nun's Hospital, Edmonton, Edmonton

V5Z 1C6

Vancouver Hospital, Vancouver

V6Z 1Y6

St Paul's Hospital, Vancouver

V8R 1J8

Royal Jubilee Hospital, Victoria

V8Z 6R5

Victoria General Hospital, Victoria

R2H 2A6

St. Boniface General Hospital, Winnipeg

R3A 1R9

Health Science Centre, Winnipeg

B3H 2Y9

Capital Health Queen Elizabeth II HSC, Halifax

L8N 4A6

St Joseph's Healthcare, Hamilton

K7L 2V7

Kingston General Hospital, Kingston

N6A 5W9

London HSC Victoria Campus, ON, London

K1H 8H6

Ottawa Hospital, Ottawa

K1Y 4E9

Ottawa Hospital Civic Hospital, Ottawa

M4N 3M5

Sunnybrook & Women's College, Toronto, Toronto

M5G 1X5

Mt Sinai Hospital, Toronto

H1T 2M4

Hopital Maisonneuve-Rosemount, Montreal

H3A 1A1

Royal Victoria Hospital, Montreal

H3G 1A4

Montreal General, Montreal

H4J 1C5

Hopital de Sacre-Coeur, Montreal

G1J 1Z4

Enfant-Jesus, Québec

Ch-1011

CHUV, Lausanne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Fresenius Kabi

INDUSTRY

lead

Daren K. Heyland

OTHER