63
Participants
Start Date
May 31, 2004
Primary Completion Date
August 31, 2007
Study Completion Date
May 31, 2010
Placement of an esophageal balloon measurements
In both groups an esophageal balloon will be placed and baseline measurements recorded. In the EP group the mechanical ventilation settings will be determined based on these measurements. In the control group measurements will be recorded but ventilation will be based in the existing standard of care wich is the ARDSnet low tidal volume ventilation study. measurements will be repeated at 24, 48 and 72 hours or as needed.
Low tidal volume ventilation
Low tidal volume ventilation strategy (ARDSnet)
Transpulmonary pressure-directed ventilation (EPVent)
Transpulmonary pressure-directed ventilation using measurements from the esophageal balloon.
Beth Israel Deaconess Medical Center, Boston
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Beth Israel Deaconess Medical Center
OTHER