62
Participants
Start Date
March 31, 2005
Primary Completion Date
July 31, 2012
Study Completion Date
September 30, 2014
Erlotinib hydrochloride
This study has 2 components: a Phase I component which estimated the MTD and DLT(s) of erlotinib given once a day during and after conventionally fractionated RT for a period of 8 weeks (DLT-evaluation period), followed by continuous administration of this medication for up to 3 years; and a Phase II component where erlotinib will be given at the MTD during and after RT for 2 years. The recommended dose of erlotinib for the Phase II component of the current study is 120mg/m2 per day (maximum dose of 200mg per day).
Duke Children's Hospital and Health Center, Durham
St. Jude Children's Research Hospital, Memphis
University of California San Diego, San Diego
Collaborators (1)
Rady Children's Hospital, San Diego
OTHER
Duke University
OTHER
St. Jude Children's Research Hospital
OTHER