Niacin Plus Statin to Prevent Vascular Events

PHASE3TerminatedINTERVENTIONAL
Enrollment

3,414

Participants

Timeline

Start Date

September 30, 2005

Primary Completion Date

September 30, 2012

Study Completion Date

December 31, 2012

Conditions
Cardiovascular DiseasesHeart DiseasesCerebrovascular AccidentCoronary DiseaseAtherosclerosisMyocardial Infarction
Interventions
DRUG

Extended release niacin

2,000 mg/day or 1,500 mg/day if higher dose not tolerated

DRUG

Simvastatin

Dose adjusted to achieve LDL-C 40 mg/dL - 80 mg/dL, adding ezetimibe (10 mg/day) if needed to achieve LDL-C target

Trial Locations (91)

10010

VA New York Harbor Healthcare System, New York

10032

Columbia University, New York

12401

Mid Valley Cardiology, Kingston

13202

Syracuse Preventive Cardiology, Syracuse

14209

Kaleida Health/Diabetes Center, Buffalo

19104

Philadelphia VA Medical Center, Philadelphia

19106

Pennsylvania Cardiology Associates, Philadelphia

19148

Cardiology Consultants of Philadelphia, Philadelphia

19718

Christiana Care Health Services, Newark

21201

University of Maryland, Baltimore

21205

Johns Hopkins University, Baltimore

22908

University of Virginia - UVA Cardiology, Charlottesville

23249

McGuire VA Medical Center, Richmond

27157

Wake Forest University - Geriatrics/Gerontology, Greensboro

Wake Forest University Health Sciences - Department of Cardiology, Winston-Salem

Wake Forest University School of Medicine - Internal Medicine/Endocrinology, Winston-Salem

27710

Duke University Medical Center, Durham

29607

Internal Medicine Associates of Greenville, Greenville

33136

University of Miami, Miami

33612

James A. Haley Veteran's Hospital, Tampa

34239

Heart & Vascular Research Center, Sarasota

35213

Cardiovascular Associates, P.C., Birmingham

35216

Clinical Research Consultants, Inc., Hoover

35294

University of Alabama, Birmingham, Birmingham

38104

VAMC Memphis - Hypertension/Lipid Research Clinic, Memphis

39216

G.V. (Sonny) Montgomery VAMC, Jackson

44115

St Vincent Charity Hospital - The Center for Vascular Health, Cleveland

44870

North Ohio Research, Ltd., Sandusky

45219

Sterling Research Group, Ltd., Cincinnati

46805

Parkview Research Center, Fort Wayne

48105

Veterans Affairs Health System of Ann Arbor, Michigan, Ann Arbor

48302

Grunberger Diabetes Institute, Bloomfield Hills

50314

Iowa Heart Center, P.C., Des Moines

52240

Lipid Research Clinic, University of Iowa, Iowa City

54401

CARE Foundation, Inc., Wausau

55106

Phalen Village Clinic, Saint Paul

55404

Berman Center for Outcomes and Clinical Research, Minneapolis

55414

University of Minnesota, Twin Cities

55454

HealthPartners Riverside Clinic, Minneapolis

55905

Mayo Clinic, Rochester

63104

St. Louis University, St Louis

68046

Alegent Health Heart & Vascular Specialists, Papillion

72205

University of Arkansas, Little Rock

77005

Kelsey Research Foundation, Houston

77030

Baylor College of Medicine, Houston

Methodist Hospital, Houston

83201

Idaho State University, Pocatello

84157

Intermountain Medical Center, Murray

85012

Carl T. Hayden VAMC Phoenix Medical Service, Pheonix

85015

Cardiovascular Consultants Ltd, Phoenix

85016

Diabetes Center of Excellence, Phoenix

85712

Tucson Clinical Research (Eastside Site), Tucson

85741

Tucson Clinical Research (Northwest Site), Tucson

87108

New Mexico VA Healthcare Systems, Albuquerque

90822

VA Long Beach Healthcare System, Long Beach

91345

Providence Holy Cross Medical Center, Mission Hills

91505

Providence Saint Joseph Medical Center, Burbank

97239

Portland VA Medical Center, Portland

98104

University of Washington, Northwest Lipid Research Center, Seattle

98105

University of Washington, Coronary Atherosclerosis Research Lab, Seattle

98108

VA Cardiology Research, Seattle

99202

Washington State University, Spokane

04074

Maine Center for Lipids & Cardiovascular Health, Scarborough

01830

Pentucket Medical Associates, Haverhill

08034

Cooper Clinical Trials Center, Cherry Hill

08318

Cardiovascular Associates of the Delaware Valley, Elmer

08903

UMDNJ -Robert Wood Johnson Medical School, New Brunswick

02906

Women's Cardiac Center at The Miriam Hospital, Providence

T2E 7C5

Heart Health Institute, Calgary

T2N 2T9

Foothills Medical Centre, Calgary

T5H 3V9

Royal Alexandra Hospital, Edmonton

V5Z 1M9

Vancouver Hospital, Vancouver

V8R 4R2

Victoria Heart Institute, Victoria

R3E 3R4

Health Sciences Center, Diabetes Research Group, Winnipeg

E2L 4L2

New Brunswick Heart Center, Saint John

A1B 3V6

Memorial University of Newfoundland, St. John's

B3H 3A6

Queen Elizabeth II Health Sciences Center, Halifax

B4N 5E3

Cardiology Associates VRH, Kentville

N1R 6V6

Cambridge Cardiac Care Center, Cambridge

K6H 4M4

McConnell Medical Center, Cornwall

P3E 2N8

Sudbury Cardiovascular Research, Greater Sudbury

L8L 2X2

Hamilton Health Sciences - General Site, Hamilton

N6A 5A5

LHSC University Hospital, London

L3Y 8C3

Newmarket Cardiology Research Group, Newmarket

M5C 2T2

St. Michael's Hospital Health Centre, Toronto

G6V 4Z5

Clinique de Cardiologie de Lévis, Lévis

H1T 1C8

Montreal Heart Institute, Montreal

G1J 1Z6

Recherches Clinicar, Québec

G1V 4M6

Clinique des maladies lipidiques de Québec, Québec

G5Y 4T8

CSSS Beauce, St-Georges de Beauce

J6V 2H2

CSSS du Sud de Lanaudière - Hôpital Pierre-Le Gardeur, Terrebonne

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Abbott

INDUSTRY

lead

Axio Research. LLC

INDUSTRY