3,414
Participants
Start Date
September 30, 2005
Primary Completion Date
September 30, 2012
Study Completion Date
December 31, 2012
Extended release niacin
2,000 mg/day or 1,500 mg/day if higher dose not tolerated
Simvastatin
Dose adjusted to achieve LDL-C 40 mg/dL - 80 mg/dL, adding ezetimibe (10 mg/day) if needed to achieve LDL-C target
VA New York Harbor Healthcare System, New York
Columbia University, New York
Mid Valley Cardiology, Kingston
Syracuse Preventive Cardiology, Syracuse
Kaleida Health/Diabetes Center, Buffalo
Philadelphia VA Medical Center, Philadelphia
Pennsylvania Cardiology Associates, Philadelphia
Cardiology Consultants of Philadelphia, Philadelphia
Christiana Care Health Services, Newark
University of Maryland, Baltimore
Johns Hopkins University, Baltimore
University of Virginia - UVA Cardiology, Charlottesville
McGuire VA Medical Center, Richmond
Wake Forest University - Geriatrics/Gerontology, Greensboro
Wake Forest University Health Sciences - Department of Cardiology, Winston-Salem
Wake Forest University School of Medicine - Internal Medicine/Endocrinology, Winston-Salem
Duke University Medical Center, Durham
Internal Medicine Associates of Greenville, Greenville
University of Miami, Miami
James A. Haley Veteran's Hospital, Tampa
Heart & Vascular Research Center, Sarasota
Cardiovascular Associates, P.C., Birmingham
Clinical Research Consultants, Inc., Hoover
University of Alabama, Birmingham, Birmingham
VAMC Memphis - Hypertension/Lipid Research Clinic, Memphis
G.V. (Sonny) Montgomery VAMC, Jackson
St Vincent Charity Hospital - The Center for Vascular Health, Cleveland
North Ohio Research, Ltd., Sandusky
Sterling Research Group, Ltd., Cincinnati
Parkview Research Center, Fort Wayne
Veterans Affairs Health System of Ann Arbor, Michigan, Ann Arbor
Grunberger Diabetes Institute, Bloomfield Hills
Iowa Heart Center, P.C., Des Moines
Lipid Research Clinic, University of Iowa, Iowa City
CARE Foundation, Inc., Wausau
Phalen Village Clinic, Saint Paul
Berman Center for Outcomes and Clinical Research, Minneapolis
University of Minnesota, Twin Cities
HealthPartners Riverside Clinic, Minneapolis
Mayo Clinic, Rochester
St. Louis University, St Louis
Alegent Health Heart & Vascular Specialists, Papillion
University of Arkansas, Little Rock
Kelsey Research Foundation, Houston
Baylor College of Medicine, Houston
Methodist Hospital, Houston
Idaho State University, Pocatello
Intermountain Medical Center, Murray
Carl T. Hayden VAMC Phoenix Medical Service, Pheonix
Cardiovascular Consultants Ltd, Phoenix
Diabetes Center of Excellence, Phoenix
Tucson Clinical Research (Eastside Site), Tucson
Tucson Clinical Research (Northwest Site), Tucson
New Mexico VA Healthcare Systems, Albuquerque
VA Long Beach Healthcare System, Long Beach
Providence Holy Cross Medical Center, Mission Hills
Providence Saint Joseph Medical Center, Burbank
Portland VA Medical Center, Portland
University of Washington, Northwest Lipid Research Center, Seattle
University of Washington, Coronary Atherosclerosis Research Lab, Seattle
VA Cardiology Research, Seattle
Washington State University, Spokane
Maine Center for Lipids & Cardiovascular Health, Scarborough
Pentucket Medical Associates, Haverhill
Cooper Clinical Trials Center, Cherry Hill
Cardiovascular Associates of the Delaware Valley, Elmer
UMDNJ -Robert Wood Johnson Medical School, New Brunswick
Women's Cardiac Center at The Miriam Hospital, Providence
Heart Health Institute, Calgary
Foothills Medical Centre, Calgary
Royal Alexandra Hospital, Edmonton
Vancouver Hospital, Vancouver
Victoria Heart Institute, Victoria
Health Sciences Center, Diabetes Research Group, Winnipeg
New Brunswick Heart Center, Saint John
Memorial University of Newfoundland, St. John's
Queen Elizabeth II Health Sciences Center, Halifax
Cardiology Associates VRH, Kentville
Cambridge Cardiac Care Center, Cambridge
McConnell Medical Center, Cornwall
Sudbury Cardiovascular Research, Greater Sudbury
Hamilton Health Sciences - General Site, Hamilton
LHSC University Hospital, London
Newmarket Cardiology Research Group, Newmarket
St. Michael's Hospital Health Centre, Toronto
Clinique de Cardiologie de Lévis, Lévis
Montreal Heart Institute, Montreal
Recherches Clinicar, Québec
Clinique des maladies lipidiques de Québec, Québec
CSSS Beauce, St-Georges de Beauce
CSSS du Sud de Lanaudière - Hôpital Pierre-Le Gardeur, Terrebonne
Lead Sponsor
Collaborators (1)
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Abbott
INDUSTRY
Axio Research. LLC
INDUSTRY