A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Positive Chronic Hepatitis B

PHASE3CompletedINTERVENTIONAL
Enrollment

266

Participants

Timeline

Start Date

June 30, 2005

Primary Completion Date

May 31, 2007

Study Completion Date

January 31, 2016

Conditions
Chronic Hepatitis B
Interventions
DRUG

TDF

300 mg tablet administered orally once daily

DRUG

ADV

10 mg tablet administered orally once daily

DRUG

TDF placebo

Tablet administered orally once daily

DRUG

ADV placebo

Tablet administered orally once daily

DRUG

FTC/TDF

200/300 mg fixed-dose combination (FDC) tablet administered orally once daily

Trial Locations (87)

1407

Sofia

1431

Sofia

2050

Camperdown

2139

Concord

2145

Westmead

3004

Prahran

3011

Footscray

3015

Rotterdam

3050

Parkville

3065

Fitzroy

3168

Clayton

4102

Woolloongabba

6000

Perth

9010

Varna

10021

New York

10029

New York

10032

New York

10969

Berlin

11355

Flushing

11526

Athens

20099

Hamburg

21229

Baltimore

22031

Fairfax

22042

Falls Church

23298

Richmond

24105

Kiel

30308

Atlanta

30309

Atlanta

30623

Hanover

33136

Miami

38043

Grenoble

40138

Bologna

40225

Düsseldorf

40237

Düsseldorf

44623

Herne

45122

Essen

46009

Valencia

48109

Ann Arbor

48202

Detroit

54500

Nancy

54642

Thessaloniki

55131

Mainz

56429

Thessaloniki

59037

Lille

62500

Brno

63104

St Louis

66421

Homburg/Saar

67901

Strasbourg

69317

Lyon

72076

Tübingen

75651

Paris

81377

München

91105

Pasadena

92105

San Diego

92110

Clichy

92868

Orange

95116

San Jose

96817

Honolulu

98101

Seattle

T2N4Z6

Calgary

V5Z1H2

Vancouver

R3E3P4

Winnepeg

M5G 2C4

Toronto

M5T 2S8

Toronto

Unknown

Hradec Králové

Auckland

Hamilton

Wellington

Whakatane

Bursa

Istanbul

Izmir

140 21

Prague

169 02

Praha 6- Stresovice

15-540

Bialystok

85-030

Bydgoszcz

41-500

Chorzów

25-317

Kielce

31-501

Krakow

01-201

Warsaw

50-136

Wroclaw

08025

Barcelona

08035

Barcelona

08907

Barcelona

06100

Ankara

B15 2TH

Birmingham

NW1 2BU

London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT00116805 - A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Positive Chronic Hepatitis B | Biotech Hunter | Biotech Hunter