Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

71

Participants

Timeline

Start Date

June 30, 2004

Primary Completion Date

April 20, 2016

Study Completion Date

December 31, 2024

Conditions
Retinoblastoma
Interventions
BIOLOGICAL

filgrastim

Given after chemo cycle for 7 days or until neutrophil counts return to normal.

DRUG

Carboplatin

Given at 28 mg/kg/dose.

DRUG

Cyclosporine

Given at 33 mg/kg/dose

DRUG

Etoposide

Given at 12 mg/kg/dose

DRUG

vincristine sulfate

Given at 0.025 mg/kg/dose for the first cycle and 0.05 mg/kg/dose for subsequent cycles if first cycle well-tolerated

PROCEDURE

cryosurgery

Local application of extreme cold to destroy residual tumor.

PROCEDURE

laser therapy

Local and precise application of laser beams to destroy residual tumor.

Trial Locations (6)

229899

Kandang Kerbau Women's and Children's Hospital, Singapore

8500000

Hospital San Juan de Dios, Santiago

V6H 3V4

Children's and Women's Hospital of British Columbia, Vancouver

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

Montreal Children's Hospital at McGill University Health Center, Montreal

600 006

Sankara Nethralaya Super Specialty Clinic, Chennai

All Listed Sponsors
collaborator

Terry Fox Foundation

OTHER

lead

The Hospital for Sick Children

OTHER