AZD2171 + Chemotherapy in Advanced NSCLC, Colorectal Cancer, or Other Cancer Suitable for Treatment With Capecitabine (Non-Small Lung Cancer Patients Closed to Enrollment as 8/9/07)

PHASE1CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

January 21, 2005

Primary Completion Date

October 23, 2009

Study Completion Date

January 18, 2011

Conditions
Colorectal CancerLung CancerUnspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

capecitabine

1000 mg/m2 orally twice daily (total of 2000 mg/m2 per day) for the first 14 days of a 21 day cycle for a maximum of 6-8 cycles.

DRUG

carboplatin

AUC 6; IV; 30 minutes; Every 21 days for a maximum of 6-8 cycles

DRUG

cediranib maleate

Given daily; orally with approximately 240 ml of water whilst in an upright position

DRUG

paclitaxel

200mg/m2; IV; 3 hours; Every 21 days for a maximum of 6-8 cycles

Trial Locations (2)

K1H 8L6

Ottawa Hospital Regional Cancer Centre - General Campus, Ottawa

M5G 2M9

Princess Margaret Hospital, Toronto

Sponsors
All Listed Sponsors
lead

NCIC Clinical Trials Group

NETWORK