Rituximab and Combination Chemotherapy in Treating Older Patients With Diffuse Large B-Cell Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

September 30, 2005

Primary Completion Date

September 30, 2014

Study Completion Date

September 30, 2014

Conditions
Lymphoma
Interventions
BIOLOGICAL

Filgrastim

5 mcg/kg, SC daily, start 24 hours after chemotherapy

BIOLOGICAL

Pegfilgrastim

6 mg SC one time (24 hours after chemotherapy)

BIOLOGICAL

Rituximab

375 mg/m\^2 intravenous piggy back (IVPB) on day 1, administered 1st

DRUG

Cyclophosphamide

750 mg/m\^2 IVPB on day 1

DRUG

Pegylated liposomal doxorubicin hydrochloride

40 mg/m\^2 IV (maximum dose 90 mg) infusion over 1 hour on day 1

DRUG

Prednisone

40 mg/m\^2 oral days 1 - 5.

DRUG

Vincristine Sulfate

2 mg IV, day 1

Trial Locations (7)

29303

CCOP - Upstate Carolina, Spartanburg

49503

CCOP - Grand Rapids, Grand Rapids

65804

Cancer Research for the Ozarks, Springfield

72913

Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith

49007-3731

CCOP - Kalamazoo, Kalamazoo

13057-4510

Hematology Oncology Associates of Central New York, PC - Northeast Center, East Syracuse

77030-4009

University of Texas M.D. Anderson CCOP Research Base, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Ortho Biotech, Inc.

INDUSTRY

lead

M.D. Anderson Cancer Center

OTHER