150
Participants
Start Date
October 31, 2004
Primary Completion Date
December 31, 2008
Study Completion Date
December 31, 2008
Nitric Oxide
Nitric oxide will be delivered for 4 hours at 80 ppm through a face mask. The dose will then be reduced to 40 ppm for 4 hours. After a total of 8 hours of treatment through face mask, the patient will get 6 mL/puls/breath of NO at 800 ppm or 3 m//pulse/breath, depending on patient weight.
Placebo
Nitrogen gas will be delivered in the same manor as the experimental drug.
St. Christopher's Hospital for Children, Philadelphia
Howard University Hospital, Washington D.C.
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda
Johns Hopkins University, Baltimore
University of Alabama, Birmingham
Colorado Sickle Cell Treatement and Research Center, Aurora
Children's Hospital Oakland, Oakland
Brigham and Women's Hospital, Boston
Childrens Hospital, Boston, Boston
Case Western Reserve University Hospital, Cleveland
Childrens Hospital, Pittsburgh, Pittsburgh
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Mallinckrodt
INDUSTRY