Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

March 31, 2007

Study Completion Date

March 31, 2007

Conditions
Lung CancerNon-Small Cell Lung Cancer
Interventions
BIOLOGICAL

Panitumumab

9.0 mg/kg on Day 1 of each 21-day cycle administered by intravenous infusion over approximately 60 minutes.

DRUG

Motesanib diphosphate

Dose-finding with an initial dose of 50 mg once daily and up to 125 mg once daily. 75 mg twice daily was also to be tested.

DRUG

Paclitaxel

Paclitaxel 200 mg/m\^2 administered by IV infusion over 3 hours.

DRUG

Carboplatin

Carboplatin was administered IV over approximately 30 minutes. Carboplatin was dosed using the glomerular filtration rate (GFR) and Calvert formula to AUC/time curve of 6 mg/mL×min.

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY