51
Participants
Start Date
January 31, 2005
Primary Completion Date
March 31, 2007
Study Completion Date
March 31, 2007
Panitumumab
9.0 mg/kg on Day 1 of each 21-day cycle administered by intravenous infusion over approximately 60 minutes.
Motesanib diphosphate
Dose-finding with an initial dose of 50 mg once daily and up to 125 mg once daily. 75 mg twice daily was also to be tested.
Paclitaxel
Paclitaxel 200 mg/m\^2 administered by IV infusion over 3 hours.
Carboplatin
Carboplatin was administered IV over approximately 30 minutes. Carboplatin was dosed using the glomerular filtration rate (GFR) and Calvert formula to AUC/time curve of 6 mg/mL×min.
Lead Sponsor
Amgen
INDUSTRY