600
Participants
Start Date
November 30, 2003
Primary Completion Date
September 30, 2006
Study Completion Date
September 30, 2007
Fluconazole
Fluconazole will be administered orally once daily. Fluconazole capsules should be taken at least one hour before or one hour after a meal. If oral drug is not possible, it will be given intravenously once daily in a total volume of 200 mL in patients \> 12 years. For adults, each 200 mL infusion will be administered over 2 hours. In patients \< 12 years, intravenous doses will be prepared.
Voriconazole
Voriconazole will be administered orally twice daily. Voriconazole capsules should be taken at least one hour before or one hour after a meal. Taken concomitantly with food, bioavailability of voriconazole is reduced. If oral drug is not possible, it will be given intravenously at a dosage of 200 mg every 12 hours over two hours in patients \> 12 years. Each voriconazole dose will be diluted to a total volume of 200 mL in patients \> 12 years. Volumes of the formulation required to provide 4 mg/kg doses for children age \< 12 years.
Memorial Sloan-Kettering Cancer Center, New York
Roswell Park Cancer Institute, Buffalo
Children's Hospital of Philadelphia, Philadelphia
University of Pennsylvania Cancer Center, Philadelphia
Children's National Medical Center, Washington D.C.
Johns Hopkins/SKCCC, Baltimore
Wake Forest University Health Sciences, Winston-Salem
Duke University Medical Center, Durham
University of Florida College of Medicine (Shands), Gainesville
H. Lee Moffitt Cancer Center, Tampa
University of Alabama at Birmingham, Birmingham
University Hospitals of Cleveland/Case Western, Cleveland
Indiana University Medical Center, Indianapolis
University of Michigan Medical Center, Ann Arbor
Karmanos Cancer Institute/BMT, Detroit
University of Minnesota, Minneapolis
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Cardinal Glennon Children's Hospital, St Louis
Washington University/Barnes Jewish Hospital, St Louis
Washington University/St. Louis Children's Hospital, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Kansas City Cancer Centers, Kansas City
University of Nebraska Medical Center, Omaha
University of Texas/MD Anderson CRC, Houston
Texas Transplant Institute, San Antonio
Utah BMT/Univ of Utah Med School, Salt Lake City
UCSD Medical Center, La Jolla
Stanford Hospital and Clinics, Stanford
Oregon Health Sciences University, Portland
Fred Hutchinson Cancer Research Center, Seattle
Dana Farber Cancer Institute/Brigham & Womens, Boston
Dana Farber Cancer Institute/Children's Hospital of Boston, Boston
Hackensack University Medical Center, Hackensack
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Blood and Marrow Transplant Clinical Trials Network
NETWORK
National Cancer Institute (NCI)
NIH
National Marrow Donor Program
OTHER
Medical College of Wisconsin
OTHER