Vaccine Treatment for Advanced Non-Small Cell Lung Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

November 30, 2003

Primary Completion Date

November 30, 2012

Study Completion Date

March 31, 2013

Conditions
Non-small Cell CarcinomaAdenocarcinoma of LungSquamous Cell CarcinomaLarge Cell CarcinomaLung Neoplasms
Interventions
BIOLOGICAL

Drug: Hyperacute Lung Cancer Cell Vaccine

At dose levels I IV the vaccine cells will be injected intradermally every four weeks for four cycles. Dosage will vary from a total of 3 x 106 to 100 x 106 HyperAcute -Lung Cancer Vaccine cells administered per vaccination cycle. At dose level V patients will receive injections of the HyperAcute -Lung Cancer Vaccine cells to include one (1) initial priming vaccine dose of 500 x 106 cells followed by seven (7) booster vaccine cell doses of 300 x 106 HyperAcute -Lung Cancer cell vaccine cells every two weeks. In Phase II, patients will receive 300 x 106 HyperAcute -Lung Cancer cell vaccine cells every two weeks for a total of 8 doses (4 months).

Trial Locations (1)

20892

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NewLink Genetics Corporation

INDUSTRY

NCT00073398 - Vaccine Treatment for Advanced Non-Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter