313
Participants
Start Date
October 31, 2003
Primary Completion Date
February 28, 2009
Study Completion Date
December 31, 2009
Valproate
250mg tablets beginning with one daily for one week, then two daily for one week, then titrated according to body weight and tolerability to achieve 10-12 mg/kg daily for 2 years, followed by a 2-month washout
Placebo
Placebo tablets beginning with one daily and increasing according to weight and perceived tolerability concerns for two years, followed by a 2-month washout
New York University Medical Center, New York
Columbia University, New York
Albany Medical Center, Albany
Syracuse VA Medical Center, Syracuse
Dent Neurologic Institute, Amherst
University of Rochester, Rochester
Global Research and Consulting, Olean
Georgetown University Medical Center, Washington D.C.
Howard University, Washington D.C.
University of Virginia, Charlottesville
Medical University of South Carolina-Columbia, Columbia
Medical University of South Carolina-Florence, Florence
Emory University, Atlanta
Pacific Research Network, San Diego
Mayo Clinic, Jacksonville
Wein Center, Mount Sinai Medical Center, Miami
Premier Research Institute, West Palm Beach
University of South Florida, Tampa
Byrd Institute, Tampa
Psychiatric Consultants, Nashville
Case Western Reserve University, University Hospitals of Cleveland, Cleveland
North East Ohio Health Services, Beachwood
Saint Mary's Health Care, Grand Rapids
Northwestern University, Chicago
Southern Illinois University, Springfield
St. Louis University, St Louis
University of Kansas, Kansas City
Sun Health Research Institute, Sun City
University of Arizona, Tucson
University of California, LA (Olive View), Los Angeles
VA Healthcare System Long Beach, Long Beach
Stanford University, VA Aging Clinical Research Center, Stanford
University of California, Irvine, Irvine
University of California, ADRC, San Diego, La Jolla
University of Southern California, Los Angeles
University of California ADRC, Los Angeles
Yale University School of Medicine, New Haven
Indiana University School of Medicine, Indianapolis
Lahey Clinic, Research Neurology, Burlington
University of Michigan, Ann Arbor
University of Nevada, Las Vegas
University of Pennsylvania, Philadelphia
Brown University, Memorial Hospital of Rhode Island, Providence
Medical University of South Carolina, North Charleston
University of Texas Southwestern Medical Center, Dallas
Southwestern Vermont Medical Center, Bennington
National Institute on Aging (NIA)
NIH
Alzheimer's Disease Cooperative Study (ADCS)
OTHER