EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan

PHASE3CompletedINTERVENTIONAL
Enrollment

3,600

Participants

Timeline

Start Date

September 30, 2003

Primary Completion Date

July 31, 2006

Study Completion Date

July 31, 2006

Conditions
Congestive Heart Failure
Interventions
DRUG

Tolvaptan

Trial Locations (378)

10011

St. Vincents Hospital and Medical Center, New York

10019

St. Lukes-Roosevelt Hospital Centers, New York

10032

New York Presbyterian Hospital, New York

11030

North Shore University Hospital, Manhasset

11576

St. Francis Hospital, Roslyn

11795

South Bay Cardiovascular Associates, West Islip

12212

Albany Associates in Cardiology, Albany

13230

SUNY, Syracuse

13790

Cardiology Associates, P.C., Johnson City

14221

Buffalo Cardiology and Pulmonary Associates, Williamsville

15224

The Western Pennsylvania Hospital, Pittsburgh

18840

Guthrie Clinic, LTD, Sayre

18960

Buxmont Cardiology Associates, PC, Sellersville

19146

Cardiology Consultants of Philadelphia, Philadelphia

19611

Cardiology Associates of West Reading, West Reading

19718

Christiana Care Health System, Newark

20422

VA Medical Center, Washington D.C.

21014

Midatlantic Cardiovascular Associates, Bel Air

21157

MidAtlantic Cardiovascular Associates, Westminster

21204

MidAtlantic Cardiovascular Associates, Towson

21218

MidAtlantic Cardiovascular Associates, Baltimore

21229

Midatlantic Cardiovascular Associates, Baltimore

21237

MidAtlantic Cardiovascular Associates, Baltimore

21286

Heart Associates, P.A., Towson

21601

Shore Health System, Easton

22031

The Cardiovascular Group PC, Fairfax

22042

Inova Institute of Research, Falls Church

22908

University of Virginia Medical Center, Charlottesville

23219

Medical College of Virginia, Richmond

23225

Cardiovascular Associates of Virginia, Richmond

24014

Roanoke Heart Institute, Roanoke

25304

CAMC Clinical Trials, Charleston

27215

Alamance Regional Medical Center, Burlington

27514

University of North Carolina, Chapel Hill

27705

Durham VA Medical Center, Durham

27710

Duke Cardiology Research, Durham

28204

Mid Carolina Cardiology, Charlotte

28735

Pitt County Memorial Hospital, The Heart Center, Greenville

28739

Hendersonville Cardiology, Hendersonville

28803

Asheville Cardiology Associates, Asheville

29204

South Carolina Heart Center, Columbia

29401

Medical University of South Carolina, Charleston

Ralph H. Johnson VAMC, Charleston

30014

Georgia Heart Specialists, Covington

30309

Cardiac Disease Specialists PC, Atlanta

30342

Atlanta Heart and Vascular Research Group, Atlanta

31403

Groupe Hospitalier Rangueil-Larrey CHU, Toulouse

32174

Cardiology Research Associates, Ormond Beach

32207

Jacksonville Heart Center, Jacksonville

32216

Jacksonville Center for Clinical Research, Jacksonville

32250

Jacksonville Heart Center, Jacksonville Beach

32901

Melbourne Internal Medicine Assoc., Melbourne

33136

University of Miami/ Jackson Memorial Hospital, Miami

33156

Miami Research and Education Foundation, Miami

33308

Cardiology Associates of Fort Lauderdale, Fort Lauderdale

33462

Florida Cardiovascular Research, Atlantis

33701

The Heart and Vascular Institute of Florida, St. Petersburg

33952

Charlotte Heart Group Research Center, Port Charlotte

34239

Cardiovascular Center of Sarasota, Sarasota

34480

Ocala Resarch Institute, Ocala

35294

University of Alabama at Birmingham, Birmingham

35801

The Heart Center, Huntsville

36608

The Heart Group, Mobile

37212

Vanderbilt Clinical Trials Center, Nashville

37388

The Cardiology Group, Tullahoma

37404

The Chattanooga Heart Institute, Chattanooga

37660

Cardiovascular Associates, Kingsport

38120

Baptist Clinical Research Center, Memphis

Stern Cardiovascular Center, Memphis

38801

Cardiology Associates of North Mississippi, Tupelo

40205

Cardiovascular Associates, Louisville

40207

Louisville Cardiology Medical Group, Louisville

43214

Midwest Cardiology Research Foundation, Columbus

43615

Northwest Ohio Cardiology Consultants, Toledo

44052

North Ohio Research Limited, Lorain

44093

Centre Hospitalo-Universitaire de Nantes-Service de Cardiologie, Nantes

44126

Cleveland Cardiovascular Research, Fairview Park

44307

Akron General Medical Center, Akron

44718

Clinical Research Limited, Canton

44870

North Ohio Research Limited, Sandusky

45219

Sterling Research Group, Cincinnati

The Lindner Clinical Trial Center, Cincinnati

45414

The Dayton Heart Center, Dayton

46260

The Care Group, Indianapolis

48085

Beaumont Hospital, Troy

48197

Michigan Heart, Ypsilanti

48201

John Dingell VA Medical Center, Detroit

48602

Covenant Medical Center, Saginaw

49770

Nisus Research, Petoskey

53121

Wisconsin Center For Clinical Research, Elkhorn

55101

Regions Hospital Cardiology Research, Saint Paul

55102

St. Paul Heart Clinic, Saint Paul

55407

Minneapolis Heart Institute, Minneapolis

55416

Hennepin County Medical Center, Minneapolis

55426

Park Nicollet Heart Center, Saint Louis Park

55455

University of Minnesota, Minneapolis

55905

Mayo Clinic, Division of Cardiology, Rochester

60015

North Shore Cardiologists, Bannockburn

60148

Midwest Heart Research Found., Lombard

60611

Northwestern University, Chicago

61603

Heart Care Midwest, Peoria

61761

Illinois Heart & Lung Associates, Normal

63110

St. Louis University, St Louis

64128

VA Medical Center- Kansas City, Kansas City

65201

Missouri Cardiovascular Specialists, Columbia

66160

Mid America Cardiology, Kansas City

68122

Heart Consultants, Omaha

68516

Bryan LGH Heart Institute, Lincoln

70043

The Louisiana Heart Center, Chalmette

70360

Leonard J Chabert Medical Center, Houma

70433

Northshore Medical Research, Covington

71103

Lousiana State University Health Sciences Center, Shreveport

71135

Cardiac Centers of LA, LLC, Shreveport

72205

Central Arkansas Veterans Healthcare Systems, Little Rock

University of Arkansas for Medical Sciences, Little Rock

73112

Integris Heart Research Center, Oklahoma City

73120

Oklahoma Cardiovascular Research Group, Oklahoma City

75230

Cardiopulmonary Research Science and Technology Institute, Dallas

76508

Scott & White Clinic Division of Cardiology, Temple

77702

Southeast Texas Cardiology Associates, Beaumont

78236

Wilford Hall Medical Center,, San Antonio

78503

McAllen Heart Clinic, McAllen

78705

Austin Cardiovascular Associates, Austin

79410

Cardiology Associates Covenant Medical Group, Lubbock

80218

Aurora Denver Cardiology Associates, Denver

80262

University of Colorado, Denver

80528

Heart and Vascular Clinic of North Colorado, Fort Collins

83642

Idaho Cardiology Associates, Meridian

83704

Idaho Cardiology Associates, Boise

84148

VA Salt Lake City Health Care System, Salt Lake City

85006

Arizona Heart Institute, Phoenix

85233

Phoenix Memorial Hospital, Gilbert

85712

Saguaro Clinical Research, Tucson

90033

LAC/USC Medical Center, Los Angeles

90073

VA Medical Center- W. Los Angeles, Los Angeles

90404

Pacific Heart Institute, Santa Monica

92077

ARI Clinical Trials, Redondo Beach

92123

San Diego Cardiac Center, San Diego

92354

Loma Linda University Medical Center, Loma Linda

92691

Mission Internal Medical Group, Mission Viejo

93301

Bakersfield Memorial Hospital, Bakersfield

Central Cardiology Medical Center, Bakersfield

94598

Cardiovascular Consultants Medical Group, Inc., Walnut Creek

94939

Cardiology Associates, Larkspur

97230

Oregon Health and Science University, Portland

99204

Empire Health Services, Spokane

Rockwood Clinic, Spokane

06360

Bakus Resesarch, Norwich

04210

Androscoggin Cardiology Associates, Auburn

04401

Northeast Cardiology Associates, Bangor

04102

Maine Medical Center, Portland

01432

Primary Care Cardiology Research, Ayer

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Medical Center, Boston

48073-1026

William Beaumont Hospital, Royal Oak

03102

New England Heart Institute, Manchester

07962-1956

Morristown Memorial Hospital, Morristown

07103

University of Medicine and Dentistry of New Jersey, Newark

07112

Newark Beth Israel Medical Center, Newark

07652

Garden State Cardiology, Paramus

02905

Rhode Island Hospital, Providence

77555-0553

University of Texas Medical Branch, Galveston

78229-3900

University of Texas Health Science Center, San Antonio

Unknown

Clinica Constituyentes de Moron, Buenos Aires

Clinica Modelo de Moron, Buenos Aires

Fundacion Favaloro, Buenos Aires

Hospital Argerich, Buenos Aires

Hospital Churruca, Buenos Aires

Hospital Eva Peron, Buenos Aires

Hospital Nacional Dr. Alejandro Posadas, Buenos Aires

Hospital de Clinicas, Capital Federal

Hospital Fernandez, Capital Federal

Hospital Italiano de Buenos Aires, Capital Federal

Hospital Privado Antartida, Capital Federal

Hospital Ramos Mejia, Capital Federal

Policlinica Bancaria, Capital Federal

"Sanatorio Municipal Julio A. Mendez", Capital Federal

Instituto de Cardiologia J. F. Cabral, Corrientes

Hospital Allende, Córdoba

Hospital Italiano de Cordoba, Córdoba

Hospital Militar de Cordoba, Córdoba

Hospital Privado Centro Medico de Cordoba, Córdoba

Hospital Central de San Isidro, San Isidro

AZ Middelheim, Antwerp

AZ Imelda Ziekenhuis, Bonheiden

Clinique St Elisabeth Place Louise, Namur

Cliniques UCL Mont-Godinne, Yvoir

I. interni kardio-angiologicka klinika LF MU, Brno

Interni oddeleni, Jablonec nad Nisou

Interni oddeleni, Náchod

Interni klinika, Oddeleni Interna I, Kardiologie, Pardubice

Interni oddeleni, Písek

I.Interni klinika, Plzen-Lochotin

I.Interni oddeleni, Prague

II.Interni klinika, Prague

Kardiologicka klinika, Prague

Kardiologicke oddeleni, Prague

Klinika kardiologie, Prague

Interni oddeleni, Ústí nad Labem

Interni klinika IPVZ, Zlín

Centre Hospitalier Regional d'Arras-Service de Cardiologie, Arras

Hopital General Henri Duffaut, Avignon

Centre Hospitalier Jeanne d'Arc, Bar-le-Duc

Hopital Louis Pradel, Bron

Cabinet de Cardiologie et d'Explorations, Essey-lès-Nancy

Centre Hospitalier, Langres

CHU Montpellier, Montpellier

Hopital Pasteur, Nice

Centre Cardiologique du Nord, Saint-Denis

Centre Hospitalier Universitaire de Nancy-Brabois, Vandœuvre-lès-Nancy

Klinikum Augsburg, Augsburg

Herzzentrum Bad Krozingen, Bad Krozingen

Herz- und Gefabklinik Bad Neustadt, Bad Neustadt-Saale

Vivantes Klinikum Neukoln, Berlin

Klinikum der Universitat zu Koln, Cologne

Akademisches Lehrkrankenhaus d. HGS Essen, Essen

Universitatsklinik Essen, Essen

Georg-August-Universitat Gottingen, Göttingen

Universitatsklinikum der, Greifswald

Klinikum der Medizinischen Fakultat, Halle

Universitatsklinikum Eppendorf, Hamburg

Medizinische Universitätsklinik, Heidelberg

Universitatsklinikum Heidelberg, Heidelberg

Universitatsklinikum des Saarland, Homburg/Saar

Friedrich Schiller Universitat Jena, Jena

University Leipzig, Leipzig

Universitatsklinikum Munster, Münster

Herz- und Diabetes Zentrum Nordrhein-Westfalen, Oeyenhausen

Universitat Regensburg, Regensburg

Marienkrankenhaus Soest, Soest

Robert-Bosch-Krankenhaus, Stuttgart

Ospedale Civile S. Giuseppe, Albano Laziale

Azienda Ospedaliera S. Michele, Cagliari

Ospedale Civile, Capri

Azienda USL n. 6 Ospedale Civile, Cecina

Poliambulatorio Valdichiana Ospedale di Cortona, Cortona

Centro Cardiologico Monzino, Milan

Ospedale Nigaurda Ca Granda, Milan

Fondazione Salvatore Maugeri, Montescano

Presidio Ospedaliero Villa Sofia, Palmero

Ospedali Riunti, Parma

IRCCS Policlinico S. Matteo, Pavia

IRCCS- Fondazione Salvatore Maugeri, Pavia

Ospedale S. Maria delle Grazie, Pozzuoli

Ospedale S. Bartolomeo, Sarzana

Ospedali Civile SS Annunziata, Sassari

Jeroen Bosch Ziekenhus (location Groot Ziekengasthius=GZG), 's-Hertogenbosch

Sint Lucas Andreas Ziekenhuis (loc. Lucas), Amsterdam

Gelre Ziekenhuis (location Juliana), Apeldoorn

Ziekenhuis Gooi Noord, Blaricum

Deventer Ziekenhuis, Deventer

Ziekenhuis Gelderse Vallei, Ede

Medisch Spectrum Twente, Enschede

Oosterschelde Ziekenhuizen, Goes

Martini Ziekenhuis (Loc. Martini Paviljoen), Groningen

Spaarne Ziekenhuis, Heemstede

Ziekenhuis Hilversum, Hilversum

Canisius-Wilhelmina Ziekenhuis, Nijmegen

Medisch Centrum Haaglanden (location Westeinde), The Hague

Isala Klinieken (Loc. Sophia), Zwolle

Hjerte med. Avd. Haukeland Universitets Sykehus, Bergen

Nordlandsykehuset, Bodø

Hjertemed.avd. Akershus Universitetssykenhus, Nordbyhagen

Diakonhjemmets sykehus Oslo, Oslo

Med. Avd. Sykenhuset Telemark, Skien

Stavanger Helseforskning, Stavanger

Oddzial Kardiologii, Bydgoszcz

Oddzial Kardiologii, Krakow

Oddzial Kardiologii, Lodz

Oddzial Kardiologiczny, Opole

Oddzial Kardiologii, Ostrowiec Świętokrzyski

Oddzial Chorob Wewnetrznych, Oława

Oddzial Kardiologiczny, Piotrkow Trybunalski

Oddzial Kardiologiczny, Płock

Oddzial Kardiologii, Sieradz

Oddzial Kardiologii, Torun

Katedra i Oddzial Kliniczny Kardiologii Slaskiej Akademii, Tychy

I Klinika Choroby Wiencowej, Warsaw

Katedra i Klinika Chorab Wewnetrznych i Kardiologii, Warsaw

Oddzial Kardiologii, Włocławek

Spitalul Judetean Brasov, Sectia de Cardiologie, Brasov

Institutul de Boli Cardiovasculare, Bucharest

Spitalul Caritas, Clinica Medicala, Bucharest

Spitalul de Urgenta Floreasca, Clinica de Cardiologie, Bucharest

Spitalul Universitar de Urgenta Bucuresti, Bucharest

Spitalul Universitar de Urgenta, Bucharest

Institutul Inimii, Prof.N. Stancioiu, Cluj-Napoca

Centrul de Cardiologie Craiova, Craiova

"Spitalul Clinic Universitar ,,Sf. Spiridon", Iași

Spitalul Clinic Judetean Mures, Târgu Mureş

Institutul de Boli Cardiovasculare Timisoara, Timișoara

Botkins Moscow City Hospital, Moscow

Burdenko Main Military Clinical Hospital, Moscow

Cardiology Research Center, Moscow

Central Clinical Hospital Presidential, Moscow

City Clinical Hospital 2, Moscow

Institute of Physico-Chemical Medicine, Moscow

Medical Center of General Management, Moscow

Moscow Medical Academy, Moscow

Moscow Regional Research Clinical Institute n.a. Vishnevsky, Moscow

Moscow State University of Medicine and Dentistry - City Hospital #11, Moscow

Moscow State University of Medicine and Dentistry - City Hospital #40, Moscow

Moscow State University of Medicine and Dentistry, Moscow

Russian State Medical University, Moscow

Veterans Hospital #3, Moscow

Cardiology Research Institute of the Ministry of Health of the Russian Federation, Saint Petersburg

City Alexandrovsky Hospital, ICU Department, Saint Petersburg

City Hospital #31, Saint Petersburg

City Hospital 8, Saint Petersburg

Military Medical Academy, Saint Petersburg

St. Elisabeth City Hospital, Saint Petersburg

St. Petersburg Clinical Hospital of Russian Academy of Sciences, Saint Petersburg

St. Petersburg Dzanelidze State Scientific Research Institute for Emergency Medical Care, Saint Petersburg

St. Petersburg Medical Postgraduate Academy, Saint Petersburg

St. Petersburg State University, Saint Petersburg

Hospital de Torrecardenas, Almería

Hospital Clinic y Provincial, Barcelona

Hospital de Cruces, Bilbao

Hospital Reina Sofia, in Cordoba, Córdoba

Hospital Doce de Octubre, Madrid

Hospital Severo Ochoa, Madrid

Hospital Universitari de Tarragona Joan XXIII, Tarragona

Hospital General Universitario de Valencia, Valencia

Avd. for intermedicin, Gothenburg

Medicinkliniken, Gothenburg

Kardiologkliniken, Linköping

Kardiologkliniken, Malmo

Forskiningsenheten,, Mölndal

Enheten for internmedicin, Karolinska Institutet, Stockholm

Hjartkliniken, M84, Stockholm

Kardiologkliniken, Stockholm

Hjartcentrum,, Umeå

Cardiologkliniken, Avd 50F, Uppsala

Cardiocentro Ticino, Lugano

Bradford Royal Infirmary, Bradford

Castle Hill Hospital, Cottingham

Leeds General Infirmary, Leeds

Northern Manchester General Hospital, Manchester

Scunthorpe General Hospital, Scunthorpe

40050-410

Hospital Santa Isabel da Santa Casa de Misericordia da Bahia, Salvador

40140-060

Fundacao Bahiana de Cardiologia- Hospital Universitario Professor Edgard Santos, Salvador

74605-050

Hospital das Clinicas da Universidade Federal de Goias, Goiânia

30130-110

Hospital Governador Israel Pinheiro, Belo Horizonte

30150-221

Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte

80730-150

Hospital Evangelico de Curitiba, Curitiba

80810-040

Hospital Nossa Senhora das Gracas, Curitiba

20020-020

Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro

90020-090

Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90035-003

Hospital das Clínicas de Porto Alegre, Porto Alegre

Hospital das Clínicas de Porto Alegre, Porto Alegre

90880-480

Hospital Mae de Deus, Porto Alegre

91350-200

Hospital Nossa Senhora da Conceica, Porto Alegre

13059-740

Hospital e Maternidade Celso Pierro, Campinas

15090-020

Hospital de Base da Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose de Rio Preto

15015-210

IMC- Instituto de Molestias Cardiovasculares, São José do Rio Preto

05403-000

Instituto do Coracao do Hospital das Clinicas- Faculdade de Medicina da Universidade de Sao Paulo, São Paulo

59012-310

Hospital Universitario Onofre Lopes, Natal

20551-030

Hospital Universitario Pedro Ernesto, Rio de Janeiro

T1Y6J4

Peter Loougheed Center, Calgary

V3V1Z2

Surrey Memorial Hospital, Surrey

V8R4R2

Victoria Heart Institute Foundation, Victoria

R2H 2A6

St. Boniface General Hospital, Winnipeg

A1B 3V6

Health Sciences Center, St. John's

L6V1B4

Brampton Research Associates, Brampton

L2E6Y2

Greater Niagara General Hospital, Niagara Falls

L1G2B9

Lakeridge Health Oshawa, Oshawa

M1E5E9

Scarborough Cardiology Research, Scarborough Village

M2S4V5

Cardiology Research Associates, Scarborough Village

M1P 2V5

The Scarborough Hospital, Toronto

M5B 1W8

St. Michael's Hospital, Toronto

M5G 2C4

University Health Network, Toronto Western Hospital, Toronto

J1H 5N4

Centre Hospitalier de l'Universite de Sherbrooke, Fleurimond

J6E6J2

CHRDL, Joliette

J4M 1E1

Invascor Clinical Research, Longueuil

H1T1C8

Montreal Heart Institute, Montreal

H3A1A1

Royal Victoria Hospital, Montreal

H3G 1A4

Montreal General Hospital, Montreal

J7Z 5T3

Hotel-Dieu de Saint-Jerome, Saint-Jérôme

All Listed Sponsors
lead

Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

NCT00071331 - EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan | Biotech Hunter | Biotech Hunter