Fludarabine and Busulfan Followed by Allogeneic Stem Cell Transplant in Treating Older Patients With Acute Myeloid Leukemia in First Complete Remission

PHASE2CompletedINTERVENTIONAL
Enrollment

121

Participants

Timeline

Start Date

January 31, 2004

Primary Completion Date

December 31, 2013

Study Completion Date

June 15, 2016

Conditions
Adult Acute Myeloid Leukemia in RemissionAcute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Interventions
BIOLOGICAL

filgrastim

Given SC

BIOLOGICAL

Anti-Thymocyte Globulin

Given IV

DRUG

busulfan

Given IV

DRUG

fludarabine phosphate

Given IV

DRUG

methotrexate

Given IV

DRUG

tacrolimus

Given PO or IV

PROCEDURE

Allogeneic Hematopoietic Stem Cell Transplantation

Undergo allogeneic PBSC transplantation

Trial Locations (21)

10021

New York Weill Cornell Cancer Center at Cornell University, New York

10029

Mount Sinai Medical Center, New York

11030

CCOP - North Shore University Hospital, Manhasset

Don Monti Comprehensive Cancer Center at North Shore University Hospital, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

11042

Monter Cancer Center of the North Shore-LIJ Health System, Lake Success

19713

CCOP - Christiana Care Health Services, Newark

19958

Tunnell Cancer Center at Beebe Medical Center, Lewes

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

21921

Union Hospital of Cecil County, Elkton

55455

Masonic Cancer Center at University of Minnesota, Minneapolis

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

02114

Massachusetts General Hospital, Boston

02115

Dana-Farber/Brigham and Women's Cancer Center, Boston

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston

02215

Beth Israel Deaconess Medical Center, Boston

08043

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township

14263-0001

Roswell Park Cancer Institute, Buffalo

27157-1096

Wake Forest University Comprehensive Cancer Center, Winston-Salem

43210-1240

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT00070135 - Fludarabine and Busulfan Followed by Allogeneic Stem Cell Transplant in Treating Older Patients With Acute Myeloid Leukemia in First Complete Remission | Biotech Hunter | Biotech Hunter