Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

August 31, 2003

Primary Completion Date

January 31, 2008

Study Completion Date

December 31, 2016

Conditions
Head and Neck CancerRadiation ToxicityXerostomia
Interventions
PROCEDURE

salivary gland transfer

Seikaly and Jha method of submandibular salivary gland transfer at the time of surgery for the primary tumor and neck nodes on Day 1

RADIATION

Post-operative radiation therapy

Dose ranging from 54-70 Gy over 5.5-7 weeks, at 2.0 Gy/fraction. Starts within 4-6 weeks of surgery.

Trial Locations (12)

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

33136

University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

53226

Medical College of Wisconsin Cancer Center, Milwaukee

53295

Veterans Affairs Medical Center - Milwaukee, Milwaukee

62702

Cancer Institute at St. John's Hospital, Springfield

32610-0232

University of Florida Shands Cancer Center, Gainesville

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

77030-4009

M. D. Anderson Cancer Center at University of Texas, Houston

T6G 1Z2

Cross Cancer Institute at University of Alberta, Edmonton

A1B 3V6

Doctor H. Bliss Murphy Cancer Centre, St. John's

G1R 2J6

Centre Hospitalier Universitaire de Quebec, Québec

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Radiation Therapy Oncology Group

NETWORK

NCT00068237 - Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer | Biotech Hunter | Biotech Hunter