55
Participants
Start Date
April 30, 2004
Primary Completion Date
October 1, 2009
Study Completion Date
December 31, 2013
rituximab
Cycles 1 and 2 only: Given IV Incremental: First dosage: \< 21 years of age: 0.5mg/kg/hr (maximum of 50 mg/hr) for the 1st hour ≥ 21 years of age: 50 mg/hr for the 1st hour. Subsequent dosages: \< 21 years of age: 1.0mg/kg/hr (maximum of 50 mg/hr) for the 1st hour ≥ 21 years of age: 100 mg/hr for the 1st hour. Days 1, 8 and 15.
cyclophosphamide
Given IV over 30-60 minutes Dose 600 mg/m2 in 50-250 mL of normal saline (NS) or Dextrose-Water 5%(D5W) (at a maximum concentration of 20 mg/ml) over 30-60 minutes on day 1 of each cycle
methylprednisolone
Methylprednisolone 0.8 mg/kg IV over 12 hours on days 1,2,3,4 and 5 of each cycle.
prednisone
Dosage 1 mg/kg orally every 12 hours on days 1,2,3,4 and 5 of each cycle. Oral prednisone may be rounded up to the nearest 2.5 mg as necessary for tablet size
Starship Children's Health, Auckland
Westmead Institute for Cancer Research at Westmead Hospital, Westmead
Royal Children's Hospital, Brisbane
Princess Margaret Hospital for Children, Perth
Mount Sinai Medical Center, New York
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York
New York Medical College, Valhalla
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Children's Hospital of Pittsburgh, Pittsburgh
Alfred I. duPont Hospital for Children, Wilmington
West Virginia University Health Sciences Center - Charleston, Charleston
Winship Cancer Institute of Emory University, Atlanta
Nemours Children's Clinic, Jacksonville
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham, Birmingham
East Tennessee Children's Hospital, Knoxville
Kosair Children's Hospital, Louisville
Cleveland Clinic Taussig Cancer Center, Cleveland
Marshfield Clinic - Marshfield Center, Marshfield
Masonic Cancer Center at University of Minnesota, Minneapolis
Mayo Clinic Cancer Center, Rochester
Children's Memorial Hospital - Chicago, Chicago
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis
Children's Mercy Hospital, Kansas City
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Cancer Institute, Oklahoma City
Medical City Dallas Hospital, Dallas
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Children's Hospital Center for Cancer and Blood Disorders, Aurora
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Kaiser Permanente Medical Center - Oakland, Sacramento
Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland
Children's Hospital and Regional Medical Center - Seattle, Seattle
Phoenix Children's Hospital, Phoenix
Southern California Permanente Medical Group, Downey
Stanford Cancer Center, Stanford
University of Florida Shands Cancer Center, Gainesville
University of Illinois Cancer Center, Chicago
University of Chicago Cancer Research Center, Chicago
Simmons Cooper Cancer Institute, Springfield
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Tulane Cancer Center Office of Clinical Research, Alexandria
C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Butterworth Hospital at Spectrum Health, Grand Rapids
CCOP - Kalamazoo, Kalamazoo
University of Mississippi Cancer Clinic, Jackson
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
Sunrise Hospital and Medical Center, Las Vegas
Hackensack University Medical Center Cancer Center, Hackensack
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Akron Children's Hospital, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Rainbow Babies and Children's Hospital, Cleveland
Nationwide Children's Hospital, Columbus
Children's Hospital of Philadelphia, Philadelphia
Vanderbilt-Ingram Cancer Center, Nashville
Methodist Children's Hospital of South Texas, San Antonio
Primary Children's Medical Center, Salt Lake City
Fletcher Allen Health Care - University Health Center Campus, Burlington
Inova Fairfax Hospital, Falls Church
Children's Hospital of The King's Daughters, Norfolk
University of Alberta Hospital, Edmonton
Children's & Women's Hospital of British Columbia, Vancouver
CancerCare Manitoba, Winnipeg
IWK Health Centre, Halifax
Hospital for Sick Children, Toronto
Montreal Children's Hospital at McGill University Health Center, Montreal
Hopital Sainte Justine, Montreal
Christchurch Hospital, Christchurch
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK