Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment

PHASE2CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

June 30, 2003

Primary Completion Date

August 31, 2007

Study Completion Date

August 31, 2007

Conditions
Brain TumorCentral Nervous System TumorsCachexiaLeukemiaLymphomaMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative DiseasesUnspecified Childhood Solid Tumor, Protocol Specific
Interventions
DRUG

cyproheptadine hydrochloride

Receive 0.25mg/kg cyproheptadine hydrochloride once daily for 4 weeks. If subject responds to treatment (stable or increased weigh), go off study. If subject does not respond (loses weigh), subject will switch to10 mg/lg/day of megestrol acetate for 4 weeks.

DRUG

megestrol acetate

Receive 0.25mg/kg cyproheptadine hydrochloride once daily for 4 weeks. If subject responds to treatment (stable or increased weigh), go off study. If subject does not respond (loses weigh), subject will switch to10 mg/lg/day of megestrol acetate for 4 weeks.

Trial Locations (43)

13210

SUNY Upstate Medical University Hospital, Syracuse

15213

Children's Hospital of Pittsburgh, Pittsburgh

32207

Nemours Children's Clinic, Jacksonville

32504

Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola

33407

Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach

33701

All Children's Hospital, St. Petersburg

44501

Tod Children's Hospital, Youngstown

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit

49503

DeVos Children's Hospital, Grand Rapids

55455

University of Minnesota Cancer Center, Minneapolis

63110

Siteman Cancer Center at Barnes-Jewish Hospital, St Louis

70118

Children's Hospital of New Orleans, New Orleans

76508

CCOP - Scott and White Hospital, Temple

78207

CHRISTUS Santa Rosa Children's Hospital, San Antonio

94609

Children's Hospital & Research Center Oakland, Oakland

96813

Cancer Research Center of Hawaii, Honolulu

97227

Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland

94609-3305

CCOP - Bay Area Tumor Institute, Oakland

20010-2970

Children's National Medical Center, Washington D.C.

32610-0296

University of Florida Shands Cancer Center, Gainesville

33677-4227

St. Joseph's Children's Hospital of Tampa, Tampa

33682-7757

CCOP - Florida Pediatric, Tampa

30912-4000

MBCCOP - Medical College of Georgia Cancer Center, Augusta

66160-7357

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

02111

Floating Hospital for Children at Tufts - New England Medical Center, Boston

48073-6769

CCOP - Beaumont, Royal Oak

55106-2049

Children's Hospitals and Clinics of Minnesota - Minneapolis, Saint Paul

07601

Tomorrows Children's Institute at Hackensack University Medical Center, Hackensack

14263-0001

Roswell Park Cancer Institute, Buffalo

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

27157-1096

Wake Forest University Comprehensive Cancer Center, Winston-Salem

44308-1062

Children's Hospital Medical Center of Akron, Akron

43205-2696

Columbus Children's Hospital, Columbus

45404-1815

Children's Medical Center - Dayton, Dayton

78229-3900

MBCCOP - South Texas Pediatrics, San Antonio

78229-3902

Methodist Cancer Center at Methodist Specialty and Transplant Hospital, San Antonio

05405-0110

Vermont Cancer Center at University of Vermont, Burlington

23298-0121

Virginia Commonwealth University Massey Cancer Center, Richmond

98105-3916

Children's Hospital and Regional Medical Center - Seattle, Seattle

54307-9070

St. Vincent Hospital Regional Cancer Center, Green Bay

H3G 1A4

Montreal Children's Hospital at McGill University Health Center, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

00912

San Jorge Children's Hospital, Santurce

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

University of South Florida

OTHER

NCT00066248 - Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment | Biotech Hunter | Biotech Hunter