Cisplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

June 30, 2003

Primary Completion Date

May 31, 2012

Study Completion Date

November 30, 2013

Conditions
Lung Cancer
Interventions
DRUG

Cisplatin

60 mg/m2 given intravenously. During RT, give on day 1 and day 22. After completion of RT, on days 43 and 64.

DRUG

Etoposide

120 mg/m2 given intravenously. During RT, give on days 1-3, then days 22-24. After completion of RT, on days 43-45 and days 64-66.

RADIATION

Radiation therapy

Large field 28.8 Gy: 1.8 Gy per fraction, 5 days per week for 16 fractions. On days 23-26, BID: use anteroposterior and posteroanterior (AP/PA) fields in a.m. at 1.8 Gy per fraction; boost with 2nd treatment in p.m. at 1.8 Gy per fraction. Then off-cord boost, 1.8 Gy, BID, x last 5 days for a total dose of 61.2 Gy in 5 wks.

Trial Locations (104)

12901

Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center, Plattsburgh

19010

Bryn Mawr Hospital, Bryn Mawr

19096

CCOP - MainLine Health, Wynnewood

Lankenau Cancer Center at Lankenau Hospital, Wynnewood

21229

St. Agnes Cancer Center, Baltimore

26003

Schiffler Cancer Center at Wheeling Hospital, Wheeling

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

Wayne Radiation Oncology, Goldsboro

27893

Wilmed Radiation Oncology Services, Wilson

35294

Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham

42101

Cancer Treatment Center at the Medical Center - Bowling Green, Bowling Green

44112

Huron Hospital Cancer Care Center, Cleveland

44119

Euclid Hospital, Cleveland

44122

South Pointe Hospital Cancer Care Center, Warrensville Heights

44124

Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

44460

Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem

44691

Cancer Treatment Center, Wooster

45044

Middletown Regional Hospital, Middletown

45267

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45428

Veterans Affairs Medical Center - Dayton, Dayton

45429

CCOP - Dayton, Dayton

Charles F. Kettering Memorial Hospital, Kettering

46107

St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove

46350

Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte

46515

Elkhart General Hospital, Elkhart

46601

CCOP - Northern Indiana CR Consortium, South Bend

Memorial Hospital of South Bend, South Bend

46617

Saint Joseph Regional Medical Center, South Bend

46904

Howard Community Hospital at Howard Regional Health System, Kokomo

48093

St. John Macomb Hospital, Warren

48106

CCOP - Michigan Cancer Research Consortium, Ann Arbor

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Seton Cancer Institute - Saginaw, Saginaw

48909

Sparrow Regional Cancer Center, Lansing

49001

Borgess Medical Center, Kalamazoo

49007

Bronson Methodist Hospital, Kalamazoo

49085

Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph, Saint Joseph

49201

Foote Hospital, Jackson

52001

Wendt Regional Cancer Center at Finley Hospital, Dubuque

53211

Columbia St. Mary's Cancer Care Center, Milwaukee

53295

Veterans Affairs Medical Center - Milwaukee, Milwaukee

54601

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse

57701

Rapid City Regional Hospital, Rapid City

61350

Community Hospital of Ottawa, Ottawa

Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa

61354

Illinois Valley Community Hospital, Peru

61356

Perry Memorial Hospital, Princeton

61362

St. Margaret's Hospital, Spring Valley

61401

Galesburg Clinic, Galesburg

Galesburg Cottage Hospital, Galesburg

61443

Kewanee Hospital, Kewanee

61455

McDonough District Hospital, Macomb

61520

Graham Hospital, Canton

61530

Eureka Community Hospital, Eureka

61554

Cancer Treatment Center at Pekin Hospital, Pekin

61615

CCOP - Illinois Oncology Research Association, Peoria

Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria

61701

St. Joseph Medical Center, Bloomington

61761

BroMenn Regional Medical Center, Normal

Community Cancer Center, Normal

62321

Memorial Hospital, Carthage

62644

Mason District Hospital, Havana

63110

Saint Louis University Cancer Center, St Louis

Siteman Cancer Center at Barnes-Jewish Hospital, St Louis

84106

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City

84107

Cottonwood Hospital Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center - Provo, Provo

84770

Dixie Regional Medical Center - East Campus, St. George

91767

Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona

94545

Saint Rose Hospital, Hayward

94546

Eden Medical Center, Castro Valley

94588

Valley Care Medical Center, Pleasanton

94602

Highland General Hospital at St. George's University School of Medicine, Oakland

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

CCOP - Bay Area Tumor Institute, Oakland

94806

J.C. Robinson, M.D. Regional Cancer Center, San Pablo

31403-3089

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

61615-7827

OSF St. Francis Medical Center, Peoria

40536-0293

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

48106-0995

St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital, Ann Arbor

48123-2500

Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

49007-3731

West Michigan Cancer Center, Kalamazoo

08755

J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River

08629

Fox Chase Cancer Center at St. Francis Medical Center, Trenton

08360

South Jersey Healthcare Regional Cancer Center, Vineland

44309-2090

Akron City Hospital, Akron

44710-1799

Aultman Hospital Cancer Center at Aultman Health Foundation, Canton

45373-1300

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

19301-1792

Paoli Memorial Hospital, Paoli

19612-6052

Reading Hospital and Medical Center, Reading

77030-4009

M.D. Anderson Cancer Center at University of Texas, Houston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Radiation Therapy Oncology Group

NETWORK

NCT00066222 - Cisplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter