Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy

PHASE3CompletedINTERVENTIONAL
Enrollment

231

Participants

Timeline

Start Date

April 30, 2003

Primary Completion Date

July 31, 2004

Study Completion Date

November 30, 2004

Conditions
Narcolepsy
Interventions
DRUG

Xyrem

Xyrem oral solution at 6 g/day for 4 weeks and 9 g/day for another 4 weeks.

DRUG

Xyrem Placebo

Xyrem Placebo oral solution 12 ml per day for 4 weeks and 18 ml per day for another 4 weeks.

DRUG

Modafinil at established dose

Modafinil oral capsules at 200 to 600 mg per day for 8 weeks.

DRUG

Modafinil (Placebo)

Modafinil Placebo oral capsules 1 to 3 capsules per day for 8 weeks.

Trial Locations (40)

14618

Sleep Disorders Center of Rochester, Rochester

Strong Sleep Disorders Center, Rochester

17013

Capital Region Sleep Disorder Center, Carlisle

18105

Lehigh Valley Hospital Sleep Disorders Center, Allentown

19444

Center for Sleep Medicine, Lafayette Hill

20815

The Center for Sleep & Wake Disorders, Chevy Chase

21204

Sleep Medicine Associates of Maryland, Towson

21921

Sleep Disorders Center -- Union Hospital of Cecil County, Elkton

27103

ALL-TRIALS Clinical Research, LLC -- Summit Sleep Disorder, Winston-Salem

27607

Raleigh Neurology Associates, Raleigh

29220

SleepMed of South Carolina, Columbia

33707

Clinical Research Group of St. Petersburg, Inc., St. Petersburg

34295

Centre du sommeil -- Hopital Gui de Chauliac, Montpellier

40217

Chest Medicine Associates DBA -- Sleep Medicine Specialists, Louisville

41017

Community Research & Sleep Management Institute, Crestview Hills

42101

Graves Gilbert Clinic, Bowling Green

43123

CSC Research -- Grove City Sleep Diagnostic Center, Grove City

45219

Cincinnati Clinic & Sleep Management Institute, Cincinnati

Community Research Management Associates,Inc., Cincinnati

46122

The Center for Sleep and Wake Disorders/Midwest Neurology, Danville

48202

Henry Ford Hospital, Detroit

57104

SDHRF Clinical Research Center, Sioux Falls

57105

Sioux Valley Clinic -- Pulmonary, Sioux Falls

Sleep Disorders Center, Sioux Falls

61603

Peoria Pulmonary Associates, Ltd, Peoria

63108

Washington University Sleep Center, St Louis

75651

Hopital Pitie Salpetriere -- Federation des Pathologies du sommeil, Paris

78229

SLEEP WALKER -- Sleep Disorders Center & Neurodiagnostics--Lung Diagnostics, Ltd., San Antonio

79410

Bhupesh Dihenia, MD, Lubbock

85006

Pulmonary Associates, PA, Phoenix

90048

Pacific Sleep Medicine Services, Inc., Los Angeles

91105

Neuro-Therapeutics, Inc., Pasadena

92121

Pacific Sleep Medicine Services, Inc., San Diego

92835

St. Jude Medical Center -- Sleep Disorders Institute, Fullerton

93042

Psychiatrische Universitatsklinik, Regensburg

94305

Stanford Sleep Disorders Clinic, Stanford

08818

New Jersey Neuroscience Institute at JFK Medical Center, Edison

29406-7108

Lowcountry Lung and Critical Care, PA, Charleston

05452

Vermont Medical Sleep Disorders Center, Inc., Essex Junction

CH-8091

Neurologische Poliklinik -- Universitats Spital Zurich, Zurich

Sponsors
All Listed Sponsors
lead

Jazz Pharmaceuticals

INDUSTRY