18
Participants
Start Date
May 31, 2003
Primary Completion Date
December 31, 2009
Study Completion Date
July 31, 2011
Aspirin
A single 81 mg aspirin tablet orally (or rectal suppository equivalent dose) given as soon as possible after start of standard iv tPA and consent.
tinzaparin sodium
A single weight-based dose of 80 anti-Xa International Units/kilogram (IU/kg)administered by subcutaneous (SQ) injection.
eptifibatide
Eptifibatide administered iv according to dose escalation group. The five dosing groups for eptifibatide are 0, 45 µg/kg bolus, 90 µg/kg bolus, 90 µg/kg bolus plus 0.25 µg/kg/min infusion for 24 hours, and 90 µg/kg bolus plus 0.5 µg/kg/min infusion for 24 hours.
Washington Hospital Center, Washington D.C.
National Institutes of Health Clinical Center, Bethesda
Suburban Hospital, Bethesda
National Institute of Neurological Disorders and Stroke (NINDS)
NIH