Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

November 30, 2003

Primary Completion Date

December 31, 2009

Study Completion Date

July 31, 2014

Conditions
Lymphoma
Interventions
DRUG

doxorubicin hydrochloride

Given IV

DRUG

mercaptopurine

Given by mouth

DRUG

methotrexate

Given IV and intrathecally

DRUG

prednisone

Given by mouth

DRUG

vinblastine sulfate

Given IV

DRUG

vincristine sulfate

Given IV

Trial Locations (159)

1011

Swiss Pediatric Oncology Group Lausanne, Lausanne

1205

Swiss Pediatric Oncology Group Geneva, Geneva

2145

Westmead Institute for Cancer Research at Westmead Hospital, Westmead

3010

Swiss Pediatric Oncology Group Bern, Bern

4029

Royal Children's Hospital, Brisbane

6001

Princess Margaret Hospital for Children, Perth

10032

Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York

10461

Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx

10595

New York Medical College, Valhalla

11040

Schneider Children's Hospital, New Hyde Park

13210

SUNY Upstate Medical University Hospital, Syracuse

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

15213

Children's Hospital of Pittsburgh, Pittsburgh

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

19803

Alfred I. duPont Hospital for Children, Wilmington

21215

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore

24014

Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke

25302

West Virginia University Health Sciences Center - Charleston, Charleston

27710

Duke Comprehensive Cancer Center, Durham

28801

Mission Hospitals - Memorial Campus, Asheville

29605

Greenville Hospital Cancer Center, Greenville

30322

Winship Cancer Institute of Emory University, Atlanta

32207

Nemours Children's Clinic, Jacksonville

32504

Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola

32806

M.D. Anderson Cancer Center at Orlando, Orlando

33021

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

33136

University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami

33155

Miami Children's Hospital, Miami

33176

Baptist-South Miami Regional Cancer Program, Miami

33316

Broward General Medical Center Cancer Center, Fort Lauderdale

33407

Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach

33607

St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa

33701

All Children's Hospital, St. Petersburg

33901

Lee Cancer Care of Lee Memorial Health System, Fort Myers

35294

Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham, Birmingham

37403

T.C. Thompson Children's Hospital, Chattanooga

37901

East Tennessee Children's Hospital, Knoxville

38105

St. Jude Children's Research Hospital, Memphis

40232

Kosair Children's Hospital, Louisville

43606

Toledo Hospital, Toledo

43614

Medical University of Ohio Cancer Center, Toledo

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

46260

St. Vincent Indianapolis Hospital, Indianapolis

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48503

Hurley Medical Center, Flint

48910

Breslin Cancer Center at Ingham Regional Medical Center, Lansing

50309

Blank Children's Hospital, Des Moines

53226

Midwest Children's Cancer Center at Children's Hospital of Wisconsin, Milwaukee

54449

Marshfield Clinic - Marshfield Center, Marshfield

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

Masonic Cancer Center at University of Minnesota, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

58122

CCOP - MeritCare Hospital, Fargo

60453

Advocate Christ Medical Center, Oak Lawn

60614

Children's Memorial Hospital - Chicago, Chicago

61637

Saint Jude Midwest Affiliate, Peoria

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

64108

Children's Mercy Hospital, Kansas City

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

72205

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock

73104

Oklahoma University Cancer Institute, Oklahoma City

75230

Medical City Dallas Hospital, Dallas

75390

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas

76104

Cook Children's Medical Center - Fort Worth, Fort Worth

78207

University of Texas Health Science Center at San Antonio, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

78723

Dell Children's Medical Center of Central Texas, Austin

79106

Texas Tech University Health Sciences Center School of Medicine - Amarillo, Amarillo

79410

Covenant Children's Hospital, Lubbock

80045

Children's Hospital Center for Cancer and Blood Disorders, Aurora

80218

Presbyterian - St. Luke's Medical Center, Denver

90027

Southern California Permanente Medical Group, Downey

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

92868

Children's Hospital of Orange County, Orange

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

95816

Sutter Cancer Center, Sacramento

95825

Kaiser Permanente Medical Center - Oakland, Sacramento

96813

Cancer Research Center of Hawaii, Honolulu

97227

Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland

98105

Children's Hospital and Regional Medical Center - Seattle, Seattle

98405

Mary Bridge Children's Hospital and Health Center - Tacoma, Tacoma

85016-7710

Phoenix Children's Hospital, Phoenix

93638-8762

Children's Hospital Central California, Madera

92123-4282

Rady Children's Hospital - San Diego, San Diego

94305-5824

Stanford Cancer Center, Stanford

06360-2875

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington

20010-2970

Children's National Medical Center, Washington D.C.

32803-1273

Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando

30912-3730

MBCCOP - Medical College of Georgia Cancer Center, Augusta

31403-3089

Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

83712-6297

Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise

60637-1470

University of Chicago Cancer Research Center, Chicago

60068-1174

Advocate Lutheran General Cancer Care Center, Park Ridge

62794-9677

Simmons Cooper Cancer Institute, Springfield

46202-5289

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

52242-1002

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

40536-0093

Lucille P. Markey Cancer Center at University of Kentucky, Lexington

71315-3198

Tulane Cancer Center Office of Clinical Research, Alexandria

02111

Floating Hospital for Children at Tufts - New England Medical Center, Boston

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

01199-0001

Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield

48109-0286

C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

49503-2560

Butterworth Hospital at Spectrum Health, Grand Rapids

49007-5381

CCOP - Kalamazoo, Kalamazoo

39216-4505

University of Mississippi Cancer Clinic, Jackson

68114-4113

Children's Hospital, Omaha

68198-6805

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha

89109-2306

CCOP - Nevada Cancer Research Foundation, Las Vegas

03756-0002

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon

07601

Hackensack University Medical Center Cancer Center, Hackensack

07962

Overlook Hospital, Morristown

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

St. Joseph's Hospital and Medical Center, Paterson

87131-5636

University of New Mexico Cancer Center, Albuquerque

11201-5493

Brooklyn Hospital Center, Brooklyn

14263-0001

Roswell Park Cancer Institute, Buffalo

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

28233-3549

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

27835-6028

Leo W. Jenkins Cancer Center at ECU Medical School, Greenville

27157-1096

Wake Forest University Comprehensive Cancer Center, Winston-Salem

44308-1062

Akron Children's Hospital, Akron

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

44106-5000

Rainbow Babies and Children's Hospital, Cleveland

43205-2696

Nationwide Children's Hospital, Columbus

45404-1815

Children's Medical Center - Dayton, Dayton

97239-3098

Oregon Health and Science University Cancer Institute, Portland

17822-0001

Geisinger Cancer Institute at Geisinger Health, Danville

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

19134-1095

St. Christopher's Hospital for Children, Philadelphia

02903

Rhode Island Hospital Comprehensive Cancer Center, Providence

57117-5039

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls

77030-2399

Baylor University Medical Center - Houston, Houston

77030-4009

M. D. Anderson Cancer Center at University of Texas, Houston

78229-3993

Methodist Children's Hospital of South Texas, San Antonio

84113-1100

Primary Children's Medical Center, Salt Lake City

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

23507-1971

Children's Hospital of The King's Daughters, Norfolk

23298-0037

Virginia Commonwealth University Massey Cancer Center, Richmond

99220-2555

Providence Cancer Center at Sacred Heart Medical Center, Spokane

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

T3B 6A8

Alberta Children's Hospital, Calgary

T6G 1Z2

University of Alberta Hospital, Edmonton

V6H 3V4

Children's & Women's Hospital of British Columbia, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

A1B 3V6

Janeway Children's Health and Rehabilitation Centre, St. John's

B3K 6R8

IWK Health Centre, Halifax

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

K7L 2V7

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

N6A 5W9

Children's Hospital of Western Ontario, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

Montreal Children's Hospital at McGill University Health Center, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

S7N 4H4

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Québec

00912

San Jorge Children's Hospital, Santurce

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00059839 - Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma | Biotech Hunter | Biotech Hunter