Phase I Study of Weekly Intravenous PS-341 (Bortezomib) Plus Mitoxantrone

PHASE1CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

March 20, 2003

Primary Completion Date

June 17, 2015

Study Completion Date

June 17, 2015

Conditions
Prostate Cancer
Interventions
DRUG

Mitoxantrone (Novantrone)

Starting dose of 3 mg/m\^2, four weekly intravenous injections (on Days 1, 8, 15 and 22) over eight 5 week cycles.

DRUG

Bortezomib (PS-341)

Starting Dose of 1.4 mg/m\^2, four weekly intravenous injections (on Days 1, 8, 15, and 22) over eight 5 week cycles.

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

Sponsors
All Listed Sponsors
collaborator

Millennium Pharmaceuticals, Inc.

INDUSTRY

collaborator

National Cancer Institute (NCI)

NIH

lead

M.D. Anderson Cancer Center

OTHER