Secondary Prevention of Small Subcortical Strokes Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

3,020

Participants

Timeline

Start Date

February 28, 2003

Primary Completion Date

April 30, 2012

Study Completion Date

April 30, 2012

Conditions
Cerebrovascular AccidentHypertension
Interventions
DRUG

aspirin

Participants receive aspirin + placebo, specifically: aspirin (325 mg) with placebo (an inactive substance). Participants will take 1 of each pill a day until the end of the study.

DRUG

clopidogrel

Participants will receive aspirin + clopidogrel, specifically: aspirin (325 mg) with clopidogrel (75 mg)-- Participants will take 1 of each pill a day until the end of the study.

OTHER

Target of Blood Pressure

Participants will be assigned to one of 2 groups of blood pressure control. The difference between the two groups is the target level of systolic blood pressure-either 130-149 mmHg or below 130 mmHg; to do so, the scientists will use medications that are already in the market for blood pressure management.

OTHER

placebo

an inactive substance

Trial Locations (63)

10032

Columbia University Medical Center, New York

10993

Helen Hayes Hospital, Haverstraw

14000

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zuibrán, Mexico City

14269

Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City

14621

Rochester General Hospital, Rochester

14642

University of Rochester, Rochester

15782

Universidad de Santiago de Compostela, Facultad de Medicina y Odontologia, Santiago de Compostela

17007

Hosp. de Girona Dr. Josep Trueta, Girona

28046

Hospital La Paz, Madrid

30303

Emory University, Grady Health System, Atlanta

33136

Miami-University of Miami, Miller School of Medicine, Miami

36617

University of Southern Alabama Stroke Center, Mobile

37232

Vanderbilt University Medical Center, Nashville

43210

Ohio State University, Division of Stroke, Columbus

44106

Case Western, Cleveland

44109

Metrohealth Medical Center, Cleveland

44280

Antiguo Hospital Civil de Guadalajara, Guadalajara

48201

Wayne State, Detroit

48202

Henry Ford Hospital, Department of Neurology, Detroit

50314

Mercy Medical Center-Ruan Neurology Clinical Research, Des Moines

53226

Medical College of Wisconsin-Neurology, Milwaukee

54449

Marshfield Clinic, Department of Neurology, Marshfield

55404

Berman Center, Minneapolis

55905

Mayo Stroke Center KA-SL-13, Rochester

63110

Tenet Health, St. Louis University, St Louis

63141

St. John's Mercy, St Louis

77030

Scurlock Stroke Center, Houston

85013

Catholic Healthcare West, Phoenix

85259

Mayo Clinic Scottsdale, Scottsdale

85724

University of Arizona, Department of Neurology, Tucson

97239

Oregon Health and Science University, Portland

644460

Hospital de La Universidad Autonoma de Nuevo Leon, Monterrey

2530116

Hospital Naval Almirante Nef, 'Subida Alessandri s/n, Hall A, Oficina 9, Viña del Mar

92103-8466

University of California San Diego Medical Center, San Diego

Unknown

University of California San Francisco-Fresno, San Francisco-Fresno

Denver, Englewood

Melbourne, Melbourne

Suburban Hospital, Bethesda

University of Washington, Sant Louis

Buffalo, Buffalo

Hospital Clinico de la Universidad Católica de Chile, Santiago

Hospital-Clinica Kennedy, Guayaquil

Hospital Sabogal Essalud-Unidad de Investigacion, Bellavista-Callao

40506-0230

University of Kentucky, Aging/Stroke Program, Lexington

02118

Boston University, Boston

08103

Cooper University Hospital, Camden

27157-1078

Wake Forest University, Sciences-Neurology, Winston-Salem

75390-8897

University of Texas Southwestern, Dallas

78229-3900

University of Texas Health Science Center, San Antonio

98104-2499

University of Washington, Seattle

T2N 2T9

Calgary Health, Calgary

V6T 2B5

SPS3 Coordinating Center, Vancouver

B3H 4V7

Halifax, Halifax

K1H 8L6

Ottawa Hospital General Campus, Ottawa

J4V 2H1

Greenfield Park, Greenfield Park

H37 1E2

McGill-Jewish General, Montreal

H3G 1A4

McGill-Montreal General, Montreal

G1J 1Z4

CHA-Hospital de l'Enfant-Jesus, Québec

08916

Hosp. Universitario Germans Trias I Pujol, Badalona

08003

Hospital Del Mar, Passeig Marítim 25-29, Barcelona

08025

Hospital de la Santa Creu I Sant Pau, c/Sant Antoni Maria Claret, 167, Barcelona

08029

Hospital del Sagrat Cor. Quinta de Salut I'Alianca, c/Viladomat 288, Barcelona

08208

Hosp. Parc Tauli de Sabadell, Barcelona

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

University of British Columbia

OTHER

NCT00059306 - Secondary Prevention of Small Subcortical Strokes Trial | Biotech Hunter | Biotech Hunter