24
Participants
Start Date
November 30, 2002
Primary Completion Date
May 31, 2005
Study Completion Date
December 31, 2006
ANTI-CD45
400ug/kg Day-5 through Day-2
CAMPATH-1H
Day -8 through Day -6 Dosed per Institutional SOP
FK506
Day -2 through Day 30 dose adjusted to maintain level between 5-15 ng/ml.
Fludarabine
Day-8 through Day-5 30 mg/m2
Total Body Irradiation
Day-1 single dose 450 cGy
Stem cell infusion
Patients will receive peripheral blood stem cells from a HLA matched or one antigen mismatched related or unrelated donor (target CD34+ cell count \>2 x 106/kg). When peripheral stem cells are unavailable or insufficient, bone marrow (target mononuclear cell count \>2 x 108/kg) will be substituted.
Texas Children's Hospital, Houston
The Methodist Hospital, Houston
The Methodist Hospital Research Institute
OTHER
Center for Cell and Gene Therapy, Baylor College of Medicine
OTHER
Baylor College of Medicine
OTHER