PS-341 Alone and PS-341 Plus EPOCH Chemotherapy to Treat Non-Hodgkin's Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

February 28, 2003

Primary Completion Date

September 30, 2008

Study Completion Date

July 31, 2009

Conditions
B-Cell Lymphoma
Interventions
DRUG

PS-341

1.3 mg/m\^2 intravenous injection days 1, 4, 8, 11 every 3 weeks

DRUG

Etoposide

50 mg/m\^2 day continuous intravenous infusion (CIV) days 1-4, 96 hour infusion. Repeat cycle every 21 days.

DRUG

Doxorubicin

10 mg/m\^2 day CIV days 1-4, 96 hour infusion. Repeat cycle every 21 days.

DRUG

Vincristine

0.4 mg/m\^2 day CIV days 1-4, 96 hour infusion. Repeat cycle every 21 days.

DRUG

Cyclophosphamide

750 mg/m\^2 day IV day 5 bolus. Repeat cycle every 21 days.

DRUG

Prednisone

60 mg/m\^2 by mouth twice a day days 1-5. Repeat cycle every 21 days.

DRUG

Filgrastim

300 micrograms subcutaneously days 6 to absolute neutrophil count recovery greater than or equal to 5000/mm\^3. Repeat cycle every 21 days.

Trial Locations (2)

14263

Roswell Parck Cancer Institute, Buffalo

20892

National Cancer Institute (NCI), Bethesda

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00054665 - PS-341 Alone and PS-341 Plus EPOCH Chemotherapy to Treat Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter