NCT00052520View on ClinicalTrials.gov

Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

September 30, 2002

Primary Completion Date

April 30, 2011

Study Completion Date

June 30, 2013

Conditions
Adult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)B-cell Adult Acute Lymphoblastic LeukemiaB-cell Childhood Acute Lymphoblastic LeukemiaChildhood Chronic Myelogenous LeukemiaChildhood Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaEssential ThrombocythemiaPolycythemia VeraPreviously Treated Myelodysplastic SyndromesRecurrent Adult Acute Lymphoblastic LeukemiaRecurrent Adult Acute Myeloid LeukemiaRecurrent Childhood Acute Lymphoblastic LeukemiaRecurrent Childhood Acute Myeloid LeukemiaRefractory Anemia With Excess BlastsRefractory Anemia With Excess Blasts in TransformationRelapsing Chronic Myelogenous LeukemiaSecondary Acute Myeloid LeukemiaT-cell Adult Acute Lymphoblastic LeukemiaT-cell Childhood Acute Lymphoblastic Leukemia
Interventions
BIOLOGICAL

therapeutic allogeneic lymphocytes

Given IV

BIOLOGICAL

aldesleukin

Given SC

PROCEDURE

peripheral blood stem cell transplantation

Undergo transplantation

PROCEDURE

allogeneic bone marrow transplantation

Undergo transplantation

OTHER

laboratory biomarker analysis

Correlative studies

GENETIC

gene expression analysis

Correlative studies

OTHER

immunologic technique

Correlative studies

OTHER

flow cytometry

Correlative studies

GENETIC

polymerase chain reaction

Correlative studies

GENETIC

cytogenetic analysis

Correlative studies

OTHER

staining method

Correlative studies

Trial Locations (1)

98109

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Fred Hutchinson Cancer Center

OTHER

NCT00052520 - Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation | Biotech Hunter | Biotech Hunter