Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

January 31, 2004

Primary Completion Date

February 28, 2009

Study Completion Date

February 28, 2009

Conditions
Brain TumorCentral Nervous System TumorsChildhood Germ Cell Tumor
Interventions
DRUG

carboplatin

Given IV

DRUG

etoposide

Given IV

DRUG

ifosfamide

Given IV

DRUG

thiotepa

Given IV

PROCEDURE

adjuvant therapy

PROCEDURE

conventional surgery

PROCEDURE

neoadjuvant therapy

PROCEDURE

peripheral blood stem cell transplantation

RADIATION

radiation therapy

craniospinal irradiation

Trial Locations (106)

1

Starship Children's Health, Auckland

1205

Swiss Pediatric Oncology Group Geneva, Geneva

3010

Swiss Pediatric Oncology Group Bern, Bern

3052

Royal Children's Hospital, Parkville

4029

Royal Children's Hospital, Brisbane

6001

Princess Margaret Hospital for Children, Perth

10016

NYU Cancer Institute at New York University Medical Center, New York

10032

Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York

10461

Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx

10595

New York Medical College, Valhalla

13210

SUNY Upstate Medical University Hospital, Syracuse

15213

Children's Hospital of Pittsburgh, Pittsburgh

19803

Alfred I. duPont Hospital for Children, Wilmington

25302

West Virginia University Health Sciences Center - Charleston, Charleston

27710

Duke Comprehensive Cancer Center, Durham

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

30322

Winship Cancer Institute of Emory University, Atlanta

32207

Nemours Children's Clinic, Jacksonville

32504

Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola

33136

University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami

33155

Miami Children's Hospital, Miami

33407

Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach

33607

St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa

33701

All Children's Hospital, St. Petersburg

33901

Lee Cancer Care of Lee Memorial Health System, Fort Myers

35294

Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham, Birmingham

38105

St. Jude Children's Research Hospital, Memphis

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

46260

St. Vincent Indianapolis Hospital, Indianapolis

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48910

Breslin Cancer Center at Ingham Regional Medical Center, Lansing

53226

Midwest Children's Cancer Center, Milwaukee

54449

Marshfield Clinic - Marshfield Center, Marshfield

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

Masonic Cancer Center at University of Minnesota, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

64108

Children's Mercy Hospital, Kansas City

72205

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock

73104

Oklahoma University Cancer Institute, Oklahoma City

75390

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas

76104

Cook Children's Medical Center - Fort Worth, Fort Worth

78207

University of Texas Health Science Center at San Antonio, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

78723

Dell Children's Medical Center of Central Texas, Austin

79410

Covenant Children's Hospital, Lubbock

90027

Childrens Hospital Los Angeles, Los Angeles

90801

Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

92868

Children's Hospital of Orange County, Orange

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94609

Children's Hospital and Research Center Oakland, Oakland

95816

Sutter Cancer Center, Sacramento

85016-7710

Phoenix Children's Hospital, Phoenix

90242-2814

Southern California Permanente Medical Group, Downey

93638-8762

Children's Hospital Central California, Madera

92123-4282

Rady Children's Hospital - San Diego, San Diego

94305-5824

Stanford Cancer Center, Stanford

06360-2875

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington

20010-2970

Children's National Medical Center, Washington D.C.

32610-0232

University of Florida Shands Cancer Center, Gainesville

32803-1273

Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando

30912-3730

MBCCOP - Medical College of Georgia Cancer Center, Augusta

60637-1470

University of Chicago Cancer Research Center, Chicago

60068-1174

Advocate Lutheran General Cancer Care Center, Park Ridge

62794-9677

Simmons Cooper Cancer Institute, Springfield

46202-5289

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

66160-7357

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02111

Floating Hospital for Children at Tufts - New England Medical Center, Boston

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

49503-2560

Butterworth Hospital at Spectrum Health, Grand Rapids

39216-4505

University of Mississippi Cancer Clinic, Jackson

07601

Hackensack University Medical Center Cancer Center, Hackensack

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

St. Joseph's Hospital and Medical Center, Paterson

87131-5636

University of New Mexico Cancer Center, Albuquerque

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

44308-1062

Akron Children's Hospital, Akron

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

43205-2696

Nationwide Children's Hospital, Columbus

45404-1815

Children's Medical Center - Dayton, Dayton

97239-3098

Oregon Health and Science University Cancer Institute, Portland

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

19104-9786

Children's Hospital of Philadelphia, Philadelphia

19134-1095

St. Christopher's Hospital for Children, Philadelphia

02903

Rhode Island Hospital Comprehensive Cancer Center, Providence

57117-5039

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls

37232-6838

Vanderbilt-Ingram Cancer Center, Nashville

78229-3993

Methodist Children's Hospital of South Texas, San Antonio

84113-1100

Primary Children's Medical Center, Salt Lake City

23507-1971

Children's Hospital of The King's Daughters, Norfolk

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

V6H 3V4

Children's & Women's Hospital of British Columbia, Vancouver

A1B 3V6

Janeway Children's Health and Rehabilitation Centre, St. John's

B3K 6R8

IWK Health Centre, Halifax

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

Montreal Children's Hospital at McGill University Health Center, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

S7N 4H4

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Québec

Unknown

Christchurch Hospital, Christchurch

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00047320 - Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors | Biotech Hunter | Biotech Hunter