Evaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes Mellitus

PHASE2CompletedINTERVENTIONAL
Enrollment

156

Participants

Timeline

Start Date

August 31, 2002

Primary Completion Date

May 31, 2003

Study Completion Date

May 31, 2003

Conditions
Diabetes Mellitus, Non-Insulin-Dependent
Interventions
DRUG

Placebo 0.01 mL

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.01 mL subcutaneously injected twice daily

DRUG

Placebo 0.02 mL

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.02 mL subcutaneously injected twice daily

DRUG

Placebo 0.03 mL

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.03 mL subcutaneously injected twice daily

DRUG

Placebo 0.04 mL

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.04 mL subcutaneously injected twice daily

DRUG

AC2993 2.5 mcg

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 2.5 mcg (0.01 mL) subcutaneously injected twice daily

DRUG

AC2993 5.0 mcg

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 5.0 mcg (0.02 mL) subcutaneously injected twice daily

DRUG

AC2993 7.5 mcg

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 7.5 mcg (0.03 mL) subcutaneously injected twice daily

DRUG

AC2993 10.0 mcg

2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 10.0 mcg (0.04 mL) subcutaneously injected twice daily

Trial Locations (33)

27511

Carolina Advanced Research, Cary

30512

Clinical Research Group of North Georgia, Blairsville

32216

Jacksonville Center for Clinical Research, Jacksonville

32605

Radiant Research-Gainsville, Gainsville

33760

Diagnostic Clinic, Clearwater

33781

Radiant Research-Pinellas Park, Pinellas Park

35209

Innovative Clinical Trials, Birmingham

35243

Healthsouth Clinical Research, Birmingham

39501

Mississippi Medical Research, LLC, Gulfport

43537

Fallen Timbers Internal Medicine, LLC, Maumee

55435

Radiant Research-Edina, Edina

60607

Cedar-Crosse Research Center, Chicago

64114

The Center for Pharmaceutical Research, Kansas City

70433

Northshore Medical Research, LLC, Covington

70458

Medical Research Institute, Slidell

75115

Healthsouth Clinical Research, DeSoto

76126

Millenium Research, Benbrook

77030

Baylor College of Medicine/Clinical Studies Unit, Houston

79705

Diabetes Center of the Southwest, Midland

80010

Anshutz Outpatient Pavilion, Aurora

83704

Radiant Research-Boise, Boise

84108

Utah Diabetes Center at the University of Utah, Salt Lake City

89119

Innovative Health Research, Las Vegas

90706

Pioneer Medical Group, Bellflower

91910

International Clinical Research Network, Chula Vista

92037

Whittier Institute for Diabetes, La Jolla

92553

Dr. Martinez Medical Clinic, Moreno Valley

92801

Endocrinology Clinic of O.C., Anaheim

93721

Bautista Research and Medical Clinic, Fresno

95032

Richard Cherlin, M.D., Los Gatos

96813

East-West Medical Research Institute, Honolulu

96814

Radiant Research-Honolulu, Honolulu

01742

Melvin Kramer, MD, Concord

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY