Navelbine, Taxol, Herceptin and Neupogen in Stage IV Breast Cancer: A Phase I - II Trial

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

March 31, 2001

Primary Completion Date

August 31, 2008

Study Completion Date

August 31, 2008

Conditions
Breast Cancer
Interventions
DRUG

Paclitaxel

50 mg/m2 IV weekly. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.

DRUG

Vinorelbine

20 mg/m2 IV weekly. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.

DRUG

Herceptin

4 mg/kg IV loading dose day 1 of first week followed by 2 mg/kg IV maintenance dose on each subsequent week. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.

DRUG

Filgrastim

5 mcg/kg daily including the day of IV chemotherapy. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.

Trial Locations (1)

98109-1023

Seattle Cancer Care Alliance, Seattle

All Listed Sponsors
collaborator

Amgen

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

GlaxoSmithKline

INDUSTRY

lead

University of Washington

OTHER