S0204 Thalidomide, Chemotherapy, and Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma

PHASE2CompletedINTERVENTIONAL
Enrollment

147

Participants

Timeline

Start Date

June 30, 2002

Primary Completion Date

October 31, 2008

Study Completion Date

October 31, 2015

Conditions
Multiple Myeloma
Interventions
BIOLOGICAL

filgrastim

PBSC collection: 10 mcg/kg SQ days 1-10

BIOLOGICAL

sargramostim

"PBSC collection: 500 mcg/m2 SQ day 1 through last apheresis~1st and 2nd trans: 500 mcg SC or IV days 6-WBC recovery"

DRUG

cyclophosphamide

PBSC collection: 1 mg/m2 IV over 45-60 mins day 0

DRUG

dexamethasone

40 mg/d PO days 1-4, 9-12, 17-20

DRUG

melphalan

"1. st trans: 140 mg/m2 IV over 20 mins day -1~2. nd trans: 200mg/m2 IV over 20 mins day -1"

DRUG

prednisone

maint: 50 mg/d PO every other day until progression

DRUG

thalidomide

ind: 50 mg increased by 50 mg every week to max 400 mg PO qhs for 35 days maint: 50 mg/d increased by 50 mg every week to 200 mg PO daily until progression

PROCEDURE

peripheral blood stem cell transplantation

2-4 x 10\^6/kg IV day 0

Trial Locations (141)

14623

Interlakes Oncology/Hematology PC, Rochester

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

26101

Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital, Parkersburg

27157

Comprehensive Cancer Center at Wake Forest University, Winston-Salem

28139

Rutherford Hospital, Rutherfordton

29303

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg

29304

CCOP - Upstate Carolina, Spartanburg

29601

Bon Secours St. Francis Health System, Greenville

29605

Greenville Hospital System Cancer Center, Greenville

29615

CCOP - Greenville, Greenville

29621

Rose Ramer Cancer Clinic at Anderson Area Medical Center, Anderson

30033

Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur

30045

Gwinnett Medical Center, Lawrenceville

30060

Kennestone Cancer Center at Wellstar Kennestone Hospital, Marietta

30106

WellStar Cobb Hospital, Austell

30274

Southern Regional Medical Center, Riverdale

30309

Piedmont Hospital, Atlanta

30342

CCOP - Atlanta Regional, Atlanta

Northside Hospital Cancer Center, Atlanta

Saint Joseph's Hospital of Atlanta, Atlanta

37916

Thompson Cancer Survival Center, Knoxville

39216

University of Mississippi Medical Center, Jackson

43015

Grady Memorial Hospital, Delaware

43055

Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark

43081

Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Riverside Methodist Hospital Cancer Care, Columbus

43215

CCOP - Columbus, Columbus

Grant Riverside Cancer Services, Columbus

43222

Mount Carmel West Hospital, Columbus

43228

Doctors Hospital at Ohio Health, Columbus

43701

Genesis - Good Samaritan Hospital, Zanesville

44307

McDowell Cancer Center at Akron General Medical Center, Akron

44903

MedCentral - Mansfield Hospital, Mansfield

45044

Middletown Regional Hospital, Middletown

45373

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45428

Veterans Affairs Medical Center - Dayton, Dayton

45429

CCOP - Dayton, Dayton

Charles F. Kettering Memorial Hospital, Kettering

45504

Mercy Medical Center Oncology Unit, Springfield

45505

Community Hospital of Springfield and Clark County, Springfield

45750

Strecker Cancer Center at Marietta Memorial Hospital, Marietta

46107

St. Francis Hospital and Health Centers, Beech Grove

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48708

Bay Regional Medical Center, Bay City

49017

Battle Creek Health System Cancer Care Center, Battle Creek

49307

Mecosta County General Hospital, Big Rapids

49423

Holland Community Hospital, Holland

49443

Hackley Hospital, Muskegon

49503

CCOP - Grand Rapids, Grand Rapids

Lacks Cancer Center at Saint Mary's Mercy Medical Center, Grand Rapids

Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids

49506

Metropolitan Hospital, Grand Rapids

49684

Munson Medical Center, Traverse City

49770

Northern Michigan Hospital, Petoskey

54601

Adena Regional Medical Center, Chillicothe

59101

CCOP - Montana Cancer Consortium, Billings

Deaconess Billings Clinic - Downtown, Billings

Hematology-Oncology Centers of the Northern Rockies - Billings, Billings

Northern Rockies Radiation Oncology Center, Billings

St. Vincent Healthcare, Billings

59107

Deaconess Billings Clinic Cancer Center, Billings

59301

Eastern Montana Cancer Center, Miles City

59405

Big Sky Oncology, Great Falls

Great Falls Clinic, Great Falls

Sletten Regional Cancer Institute, Great Falls

59601

St. Peter's Hospital, Helena

59701

St. James Community Hospital, Butte

59715

Bozeman Deaconess Hospital, Bozeman

Internal Medicine Associates of Bozeman, Bozeman

59801

Community Medical Center, Missoula

59802

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula

Montana Cancer Specialists at Montana Cancer Center, Missoula

59804

Judy L. Schmidt, MD, FACP, P. C., Missoula

59901

Glacier Oncology, PLLC, Kalispell

Kalispell Medical Oncology, Kalispell

Kalispell Regional Medical Center, Kalispell

60153

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood

64131

CCOP - Kansas City, Kansas City

66160

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

66604

Stormont-Vail Cancer Center, Topeka

66606

St. Francis Comprehensive Cancer Center, Topeka

67214

Wesley Medical Center, Wichita

67401

Salina Regional Health Center, Salina

71130

Feist-Weiller Cancer Center at Louisiana State University Health Sciences, Shreveport

71210

Louisiana State University Health Sciences Center - Monroe, Monroe

72205

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock

78234

Brooke Army Medical Center, Fort Sam Houston

78236

Wilford Hall Medical Center, Lackland Air Force Base

79415

UMC Southwest Cancer and Research Center, Lubbock

82801

Welch Cancer Center, Sheridan

83712

St. Luke's Mountain States Tumor Institute - Boise, Boise

95616

University of California Davis Cancer Center, Davis

95661

Sutter Roseville Medical Center, Roseville

95806

Providence St. Peter Hospital Regional Cancer Center, Olympia

95816

Sutter Cancer Center, Sacramento

96701

Kapiolani Medical Center at Pali Momi, ‘Aiea

96813

Cancer Research Center of Hawaii, Honolula

OnCare Hawaii, Incorporated - Lusitana, Honolulu

Queen's Cancer Institute at Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Incorporated, Honolulu

96817

OnCare Hawaii, Incorporated - Kuakini, Honolulu

St. Francis Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97030

Legacy Mount Hood Medical Center, Glesham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center, Portland

97213

Providence Cancer Center at Providence Portland Medical Center, Portland

97222

Providence Milwaukie Hospital, Milwaukie

97225

CCOP - Columbia River Oncology Program, Portland

Providence St. Vincent Medical Center, Portland

97227

Institute of Oncology at Vilnius University, Portland

97239

Cancer Institute at Oregon Health and Science University, Portland

98002

Auburn Regional Center for Cancer Care, Auburn

98003

St. Francis Hospital, Federal Way

98104

Fred Hutchinson Cancer Research Center, Seattle

Group Health Central Hospital, Seattle

Harborview Medical Center, Seattle

98114

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle

98195

University Cancer Center at University of Washington Medical Center, Seattle

98225

St. Joseph Hospital Community Cancer Center, Bellingham

98273

Skagit Valley Hospital Cancer Care Center, Mount Vernon

98284

North Puget Oncology at United General Hospital, Sedro-Woolley

98310

Olympic Hematology and Oncology, Bremerton

98372

Good Samaritan Cancer Center, Puyallup

98405

Allenmore Hospital, Tacoma

CCOP - Northwest, Tacoma

St. Joseph Medical Center at Franciscan Health System, Tacoma

98499

St. Clare Hospital, Tacoma

98507

Capital Medical Center, Olympia

98531

Regional Cancer Center at Providence Hospital, Centralia

98668

Southwest Washington Medical Center Cancer Center, Vancouver

98801

Central Washington Hospital, Wenatchee

Wenatchee Valley Clinic, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

45433-5529

United States Air Force Medical Center Wright-Patterson, Wright-Patterson AFB

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK

NCT00040937 - S0204 Thalidomide, Chemotherapy, and Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma | Biotech Hunter | Biotech Hunter