Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

266

Participants

Timeline

Start Date

August 31, 2002

Primary Completion Date

August 31, 2009

Study Completion Date

March 31, 2010

Conditions
HIV Infections
Interventions
DRUG

NRTIs (ABC, FTC, FTC/TDF, 3TC, 3TC/AZT, d4T, TDF, ddC, AZT)

Accepted NRTIs: abacavir sulfate (ABC), emtricitabine (FTC), emtricitabine/Tenofovir disoproxil fumarate (FTC/TDF), lamivudine (3TC), lamivudine/zidovudine (3TC/AZT), stavudine (d4T), tenofovir disoproxil fumarate (TDF), zalcitabine (ddC), zidovudine (AZT) Prescribed per participant's doctor

DRUG

NNRTIs (EFV, NVP)

"Accepted NNRTIs: efavirenz (EFV), nevirapine (NVP)~Prescribed per participant's doctor"

DRUG

PIs (AMP, IDV, LPV/r, NFV, SQV, RTV)

"Accepted PIs: amprenavir (APV). indinavir sulfate (IDV), lopinavir/ritonavir (LPV/r), nelfinavir mesylate (NFV), saquinavir (SQV), ritonavir (RTV)~Prescribed per participant's doctor"

Trial Locations (31)

10016

Nyu Ny Nichd Crs, New York

10032

Columbia IMPAACT CRS, New York

10037

Harlem Hosp. Ctr. NY NICHD CRS, New York

10461

Jacobi Med. Ctr. Bronx NICHD CRS, The Bronx

13210

SUNY Upstate Med. Univ., Dept. of Peds., Syracuse

20060

Howard Univ. Washington DC NICHD CRS, Washington D.C.

33136

Univ. of Miami Ped. Perinatal HIV/AIDS CRS, Miami

33316

South Florida CDTC Ft Lauderdale NICHD CRS, Fort Lauderdale

33606

USF - Tampa NICHD CRS, Tampa

38105

St. Jude/UTHSC CRS, Memphis

60614

Chicago Children's CRS, Chicago

60637

Univ. of Chicago - Dept. of Peds., Div. of Infectious Disease, Chicago

70112

Tulane Univ. New Orleans NICHD CRS, New Orleans

77030

Texas Children's Hospital CRS, Houston

90806

Miller Children's Hosp. Long Beach CA NICHD CRS, Long Beach

91803

Usc La Nichd Crs, Alhambra

94609

Children's Hosp. & Research Ctr. Oakland, Ped. Clinical Research Ctr. & Research Lab., Oakland

97239

Oregon Health & Science Univ. - Dept. of Peds., Div. of Infectious Disease, Portland

98105

Seattle Children's Hospital CRS, Seattle

90027-6062

Children's Hospital of Los Angeles NICHD CRS, Los Angeles

90095-1752

UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CRS, Los Angeles

06106

Connecticut Children's Med. Ctr., Hartford

32610-0296

Univ. of Florida College of Medicine-Dept of Peds, Div. of Immunology, Infectious Diseases & Allergy, Gainesville

01605

WNE Maternal Pediatric Adolescent AIDS CRS, Worcester

63110-1010

Washington University Therapeutics (WT) CRS, St Louis

08901-1969

UMDNJ - Robert Wood Johnson Med. School, Div. of Allergy, Immunology & Infectious Diseases, New Brunswick

07103

Rutgers - New Jersey Medical School CRS, Newark

11794-8111

SUNY Stony Brook NICHD CRS, Stony Brook

27599-7220

UNC at Chapel Hill School of Medicine - Dept. of Peds., Div. of Immunology & Infectious Diseases, Chapel Hill

00935

Univ. of Puerto Rico Ped. HIV/AIDS Research Program CRS, San Juan

00936

San Juan City Hosp. PR NICHD CRS, San Juan

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

PENTA Foundation

NETWORK

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00039741 - Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children | Biotech Hunter | Biotech Hunter