Chemotherapy, Imatinib Mesylate, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

PHASE2CompletedINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

April 30, 2002

Primary Completion Date

April 30, 2012

Study Completion Date

February 28, 2014

Conditions
Adult Acute Lymphoblastic Leukemia in Remission
Interventions
DRUG

imatinib mesylate

Given PO

DRUG

methotrexate

Given IT and IV

DRUG

vincristine sulfate

Given IV

DRUG

leucovorin calcium

Given IV and PO

PROCEDURE

peripheral blood stem cell transplantation

Undergo PBSCT

PROCEDURE

autologous hematopoietic stem cell transplantation

Undergo autologous PBSCT

PROCEDURE

allogeneic hematopoietic stem cell transplantation

Undergo allogeneic PBSCT

RADIATION

total-body irradiation

Undergo TBI

DRUG

tacrolimus

Given IV or PO

BIOLOGICAL

filgrastim

Given SC

DRUG

etoposide

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

cytarabine

Given IV

OTHER

laboratory biomarker analysis

Correlative studies

Trial Locations (97)

10065

Weill Medical College of Cornell University, New York

11030

North Shore University Hospital, Manhasset

North Shore-LIJ Health System CCOP, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

North Shore-LIJ Health System/Center for Advanced Medicine, New Hyde Park

13126

Oswego Hospital, Oswego

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

23298

Virginia Commonwealth University, Richmond

27157

Wake Forest University Health Sciences, Winston-Salem

28501

Kinston Medical Specialists PA, Kinston

29425

Medical University of South Carolina, Charleston

30342

Blood and Marrow Transplant Group of Georgia, Atlanta

43210

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

46845

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne

59101

Montana Cancer Consortium CCOP, Billings

Northern Rockies Radiation Oncology Center, Billings

Saint Vincent Healthcare, Billings

59102

Hematology-Oncology Centers of the Northern Rockies PC, Billings

59107

Deaconess Medical Center, Billings

59405

Berdeaux, Donald MD (UIA Investigator), Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Deaconess Cancer Center, Bozeman

Bozeman Deaconess Hospital, Bozeman

Internal Medicine of Bozeman, Bozeman

59801

Community Medical Hospital, Missoula

59802

Montana Cancer Specialists, Missoula

Saint Patrick Hospital - Community Hospital, Missoula

59804

Guardian Oncology and Center for Wellness, Missoula

59901

Glacier Oncology PLLC, Kalispell

Kalispell Medical Oncology, Kalispell

Kalispell Regional Medical Center, Kalispell

60153

Loyola University Medical Center, Maywood

60637

University of Chicago, Chicago

60640

Weiss Memorial Hospital, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois Valley Hospital, Peru

61356

Perry Memorial Hospital, Princeton

61362

Saint Margaret's Hospital, Spring Valley

61401

Galesburg Cottage Hospital, Galesburg

Illinois CancerCare Galesburg, Galesburg

61455

Mcdonough District Hospital, Macomb

61520

Graham Hospital Association, Canton

61530

Eureka Hospital, Eureka

61554

Pekin Cancer Treatment Center, Pekin

Pekin Hospital, Pekin

61603

Methodist Medical Center of Illinois, Peoria

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

Illinois Oncology Research Association CCOP, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Saint Joseph Medical Center, Bloomington

61747

Hopedale Medical Complex - Hospital, Hopedale

61761

Bromenn Regional Medical Center, Normal

Community Cancer Center Foundation, Normal

62321

Memorial Hospital, Carthage

62644

Mason District Hospital, Havana

63110

Washington University School of Medicine, St Louis

64057

Centerpoint Medical Center LLC, Independence

64068

Liberty Hospital, Liberty

64111

Saint Luke's Cancer Institute, Kansas City

64114

Radiation Oncology Practice Corporation South, Kansas City

64154

Radiation Oncology Practice Corporation - North, Kansas City

66044

Lawrence Memorial Hospital, Lawrence

66061

Radiation Oncology Center of Olathe, Olathe

66112

Providence Medical Center, Kansas City

66210

Radiation Oncology Practice Corporation Southwest, Overland Park

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Main Office, Wichita

Via Christi Regional Medical Center, Wichita

Wichita CCOP, Wichita

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

Salina Regional Health Center, Salina

67801

Cancer Center of Kansas - Dodge City, Dodge City

82801

Welch Cancer Center, Sheridan

04401

Eastern Maine Medical Center, Bangor

01915

Beverly Hospital, Beverly

01930

Addison Gilbert Hospital, Gloucester

01605

Commonwealth Hematology Oncology PC-Worcester, Worcester

59107-7000

Billings Clinic, Billings

03431

Cheshire Medical Center-Dartmouth-Hitchcock Keene, Keene

03867

Frisbie Hospital, Rochester

15224-1791

Western Pennsylvania Hospital, Pittsburgh

05819

Northeastern, St. Johnsbury

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00039377 - Chemotherapy, Imatinib Mesylate, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | Biotech Hunter | Biotech Hunter