78
Participants
Start Date
February 28, 2002
Primary Completion Date
December 31, 2004
Study Completion Date
April 30, 2009
filgrastim
Cycle 1: 300 ug (BW \< = 70 kg) or 480ug (BW \>70 kg) sub Q injection Day 6 until ANC \> 5000/uL after nadir counts Subsequent cycle dosages based on previous cycle toxicity or Day 1 Tx toxicity
rituximab
375 mg/sq m IV infusion Day 1 Cycle 1 Subsequent cycle dosage based on previous cycle or day 1 of tx toxicities
cyclophosphamide
750 mg/sq m IV infusion on Day 5 Cycle 1 Subsequent cycle dosage based on previous cycle or day 1 treatment toxicities
doxorubicin hydrochloride
10 mg/sq m/day continuous IV infusion on Days 1-4 Cycle 1 Subsequent cycle dosages based on previous cycle and Day 1 treatment toxicities
etoposide
50 mg/sq m/day continuous IV infusion Days 1-4 Cycle 1 Subsequent cycle dosages based on previous cycle and day 1 of treatment toxicities
prednisone
60 mg/sq m PO bid days 1-5 of ea cycle
vincristine sulfate
0.4 mg/sq m/day continuous IV infusion uncapped on Days 1-4 Cycle 1 Subsequent cycle dosages based on previous cycle and day 1 of treatment toxicities
Memorial Sloan-Kettering Cancer Center, New York
New York Weill Cornell Cancer Center at Cornell University, New York
Mount Sinai Medical Center, NY, New York
CCOP - North Shore University Hospital, Manhasset
North Shore University Hospital, Manhasset
Elmhurst Hospital Center, Elmhurst
Queens Cancer Center of Queens Hospital, Jamaica
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., East Syracuse
University Hospital at State University of New York - Upstate Medical University, Syracuse
Veterans Affairs Medical Center - Syracuse, Syracuse
Veterans Affairs Medical Center - Buffalo, Buffalo
Western Pennsylvania Hospital, Pittsburgh
CCOP - Christiana Care Health Services, Newark
Lombardi Cancer Center at Georgetown University Medical Center, Washington D.C.
Veterans Affairs Medical Center - Washington, DC, Washington D.C.
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
Martha Jefferson Hospital, Charlottesville
Virginia Oncology Associates - Norfolk, Norfolk
Oncology and Hematology Associates of Southwest Virginia, Inc., Roanoke
St. Mary's Medical Center, Huntington
Veterans Affairs Medical Center - Durham, Durham
Duke Comprehensive Cancer Center, Durham
NorthEast Oncology Associates, Concord
FirstHealth Moore Regional Hospital, Pinehurst
Veterans Affairs Medical Center - Asheville, Asheville
Florida Hospital Cancer Institute, Orlando
Memorial Regional Hospital Comprehensive Cancer Center, Hollywood
CCOP - Mount Sinai Medical Center, Miami Beach
Broward General Medical Center, Fort Lauderdale
Palm Beach Cancer Institute, West Palm Beach
Northeast Alabama Regional Medical Center, Anniston
Baptist Hospital East - Louisville, Louisville
CCOP - Northern Indiana CR Consortium, South Bend
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph, Saint Joseph
Hematology Oncology Associates of the Quad Cities, Bettendorf
Veterans Affairs Medical Center - Minneapolis, Minneapolis
University of Minnesota Cancer Center, Minneapolis
West Suburban Center for Cancer Care, River Forest
Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago
Louis A. Weiss Memorial Hospital, Chicago
Saint Anthony Medical Center, Rockford
CCOP - Illinois Oncology Research Association, Peoria
Barnes-Jewish Hospital, St Louis
Missouri Baptist Cancer Center, St Louis
CCOP - Kansas City, Kansas City
Veterans Affairs Medical Center - Columbia (Truman Memorial), Columbia
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center, Oklahoma City
Veterans Affairs Medical Center - Dallas, Dallas
CCOP - Southern Nevada Cancer Research Foundation, Las Vegas
Veterans Affairs Medical Center - Las Vegas, Las Vegas
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center, Los Angeles
Veterans Affairs Medical Center - San Diego, San Diego
UCSF Comprehensive Cancer Center, San Francisco
Veterans Affairs Medical Center - San Francisco, San Francisco
Rebecca and John Moores UCSD Cancer Center, La Jolla
Naval Medical Center - San Diego, San Diego
Walter Reed Army Medical Center, Washington D.C.
University of Chicago Cancer Research Center, Chicago
Fort Wayne Medical Oncology and Hematology, Incorporated, Fort Wayne
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
University of Massachusetts Memorial Medical Center - University Campus, Worcester
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
New Hampshire Oncology-Hematology, PA - Hooksett, Hooksett
Norris Cotton Cancer Center at Dartmouth Medical School, Lebanon
Cooper University Hospital, Camden
Roswell Park Cancer Institute, Buffalo
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Cape Fear Valley Health System, Fayetteville
Lenoir Memorial Hospital Cancer Center, Kinston
New Hanover Regional Medical Center, Wilmington
CCOP - Southeast Cancer Control Consortium, Winston-Salem
Comprehensive Cancer Center at Wake Forest University, Winston-Salem
Arthur G. James Cancer Hospital - Ohio State University, Columbus
Lifespan: The Miriam Hospital, Providence
Green Mountain Oncology Group, Bennington
Vermont Cancer Center at University of Vermont, Burlington
MBCCOP - Massey Cancer Center, Richmond
Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus, San Juan
National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER