Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates

PHASE3CompletedINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

December 31, 1997

Primary Completion Date

February 29, 2008

Study Completion Date

April 30, 2008

Conditions
Herpes Simplex
Interventions
DRUG

Acyclovir

Oral banana flavored acyclovir suspension: 300 mg/m\^2/dose three times a day (TID), to be given at least 6 to 8 hours apart for 6 months. Dosage adjustments will be made monthly to compensate for increases in body surface area.

DRUG

Placebo

Oral banana flavored placebo suspension: to be given at least 6 to 8 hours apart for 6 months. Dosage adjustments will be made monthly to compensate for increases in body surface area.

Trial Locations (29)

10029

Mount Sinai Hospital, New York

13210

UNY Upstate Medical University Hospital - Pediatrics, Syracuse

21287

Johns Hopkins Hospital, Baltimore

28203

Carolinas Medical Center, Charlotte

29425

Medical University of South Carolina, Charleston

32209

University of Florida - College of Medicine - Jacksonville, Jacksonville

35233

University of Alabama at Birmingham, Birmingham

40202

Kosair Children's Hospital, Louisville

43205

Nationwide Children's Hospital - Infectious Diseases, Columbus

45231

Cincinnati Children's Hospital Medical Center, Cincinnati

48201

Children's Hospital of Michigan - Pediatric Infectious Diseases, Detroit

60637

The University of Chicago - Comer Children's Hospital - Infectious Diseases, Chicago

63110

St. Louis Children's Hospital - Infectious Disease, St Louis

70112

Tulane University - Tulane Medical Center - Department of Pediatrics, New Orleans

72202

Arkansas Children's Hospital, Department of Infectious Diseases, Little Rock

76104

Cook Children's Infectious Disease Services, Fort Worth

78229

University of Texas Health Science Center San Antonio - Pediatrics - Immunology & Infectious Disease, San Antonio

90027

Children's Hospital Los Angeles - Pediatrics Infectious Diseases, Los Angeles

92123

Rady Children's Hospital San Diego, San Diego

98105

Seattle Children's Hospital - Infectious Diseases, Seattle

94305-5208

Stanford University School of Medicine, Stanford

04101

Maine Medical Center - Department of Pediatric Specialty Care - Infectious Disease, Portland

39216-4505

University of Mississippi, Jackson

44109-1998

MetroHealth Medical Center - Pediatric Infectious Disease, Cleveland

97201-3098

Oregon Health and Science University, Portland

02903

Rhode Island Hospital, Providence

37232-2581

Vanderbilt University, Nashville

75390-9063

University of Texas Southwestern Medical Center, Dallas

T6R 2C2

University of Alberta - Aberhart Centre - Pediatrics, Edmonton

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00031460 - Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates | Biotech Hunter | Biotech Hunter