Paclitaxel With or Without Bevacizumab in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

722

Participants

Timeline

Start Date

January 29, 2002

Primary Completion Date

November 30, 2006

Study Completion Date

May 31, 2009

Conditions
Breast Cancer
Interventions
DRUG

bevacizumab

10 mg/kg following paclitaxel treatment on weeks 1 and 3 of every 4-week cycle

DRUG

Paclitaxel

90 mg/m2 IV infusion over 1 hour every week for 3 weeks followed by 1 week rest

Trial Locations (30)

29303

CCOP - Upstate Carolina, Spartanburg

32224

Mayo Clinic - Jacksonville, Jacksonville

36607

MBCCOP - Gulf Coast, Mobile

45429

CCOP - Dayton, Dayton

48106

CCOP - Michigan Cancer Research Consortium, Ann Arbor

54301

CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay

55416

CCOP - Metro-Minnesota, Saint Louis Park

55805

CCOP - Duluth, Duluth

55905

Mayo Clinic Cancer Center, Rochester

56303

CentraCare Health Plaza, Saint Cloud

57104

CCOP - Sioux Community Cancer Consortium, Sioux Falls

57709

Rapid City Regional Hospital, Rapid City

58122

CCOP - Merit Care Hospital, Fargo

58201

Altru Cancer Center, Grand Forks

61602

CCOP - Illinois Oncology Research Association, Peoria

61801

CCOP - Carle Cancer Center, Urbana

68106

CCOP - Missouri Valley Cancer Consortium, Omaha

70121

CCOP - Ochsner, New Orleans

74136

CCOP - Oklahoma, Tulsa

85259-5404

CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale

30342-1701

CCOP - Atlanta Regional, Atlanta

52403-1206

CCOP - Cedar Rapids Oncology Project, Cedar Rapids

50309-1016

CCOP - Iowa Oncology Research Association, Des Moines

51101-1733

Siouxland Hematology-Oncology, Sioux City

58501-5505

Medcenter One Health System, Bismarck

43623-3456

CCOP - Toledo Community Hospital, Toledo

17822-2001

CCOP - Geisinger Clinic and Medical Center, Danville

15212-4772

Allegheny General Hospital, Pittsburgh

V5Z 4E6

British Columbia Cancer Agency, Vancouver

S4T 7T1

Allan Blair Cancer Centre, Regina

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

North Central Cancer Treatment Group

NETWORK

collaborator

NCIC Clinical Trials Group

NETWORK

collaborator

NSABP Foundation Inc

NETWORK

lead

Eastern Cooperative Oncology Group

NETWORK